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BioMed Research International
Volume 2013, Article ID 896536, 6 pages
Research Article

Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes

1PPG em Promoção da Saúde, Universidade de Santa Cruz do Sul, Avenida Independência, 2293, Sala 4206, 96815-900 Santa Cruz do Sul, RS, Brazil
2Curso de Nutrição/DEDFIS, Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil
3Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

Received 10 April 2013; Revised 18 June 2013; Accepted 23 June 2013

Academic Editor: Norma Possa Marroni

Copyright © 2013 Silvia Isabel Rech Franke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hyperglycemia leads to the formation of free radicals and advanced glycation end-products (AGEs). Antioxidants can reduce the level of protein glycation and DNA damage. In this study, we compared the levels of vitamin C intake, which is among the most abundant antioxidants obtained from diet, with the levels of fasting plasma glucose (FPG), glycated hemoglobin (A1C), DNA damage, and cytotoxicity in prediabetic subjects and type 2 diabetic subjects. Our results indicated that there was no significant correlation between FPG or A1C and DNA damage parameters (micronuclei, nucleoplasmic bridges, and nuclear buds). FPG and A1C correlated with necrosis ( ; and ; , resp.). Vitamin C intake correlated negatively with necrosis and apoptosis ( ; , and ; , resp.). The lack of a correlation between the FPG and A1C and DNA damage could be explained, at least in part, by the elimination of cells with DNA damage by either necrosis or apoptosis (cytotoxicity). Vitamin C appeared to improve cell survival by reducing cytotoxicity. Therefore, the present results indicate the need for clinical studies to evaluate the effect of low-dose vitamin C supplementation in type 2 diabetes.