No Association of IFNG+874T/A SNP and NOS2A-954G/C SNP Variants with Nitric Oxide Radical Serum Levels or Susceptibility to Tuberculosis in a Brazilian Population Subset

Table 3

Combined genotype analysis of IFNG+874T/A and NOS2A-954G/C SNPs in tuberculosis patients and control groups.

Combined genotypes	Tuberculosis patients; 𝑛=172 (%)	Control groups
		𝑛=179 (%)	𝑃^1	OR	TST+ 𝑛=98 (%)	𝑃^2	OR
AA/GG	62 (36.0)	56 (31.3)	0.40	1.00	33 (33.7)	0.79	1.00
AA/GC	9 (5.2)	5 (2.8)		1.63	4 (4.1)		1.20
AA/CC	1 (0.6)	1 (0.6)		0.90	1 (1.0)		0.53
AT/GG	70 (40.7)	80 (44.7)		0.79	39 (39.8)		0.96
AT/GC	8 (4.7)	11 (6.1)		0.66	9 (9.2)		0.47
TT/GG	20 (11.6)	24 (13.4)		0.75	12 (12.2)		0.89
TT/GC	2 (1.2)	2 (1.1)		0.90	0 (0)		ND

The AA/GG combined genotype was used as reference in a 7 × 2 𝜒² for trend table. The combined genotypes TT/GG and AT/GG were not present.
𝑃-value considered 𝑃≤0.05; 𝑃¹-value comparing TB patients and control group.
𝑃²-value comparing TB patients and TST+ control subgroup.
TST+: tuberculin skin test positive; OR: odds ratio; ND: not determined.