Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients

Table 5

Comparison of patients’ clinical status during hospitalization.

Outcome	Total	NLTX	Placebo	P value
		𝑛=27	𝑛=27
Abnormality
Loss of consciousness	10 (18.5%)	0 (0.0%)	10 (37.0%)	<0.01*
Bradypnea	11 (20.4%)	0 (0.0%)	11 (40.7%)	<0.01*
Apnea	5 (9.3%)	0 (0.0%)	5 (18.5%)	0.02*
ABG
Respiratory acidosis & hypercapnia	8 (14.8%)	1 (3.7%)	7 (25.9%)	0.05**
Hypoxia	9 (16.7%)	1 (3.7%)	8 (29.6%)	0.02**
Taking naloxone bolus	13 (24.1%)	1 (3.7%)	12 (44.4%)	<0.01*
Other clinical status
Naloxone iv Infusion	10 (18.5%)	0 (0.0%)	10 (37.0%)	<0.01*
Need for ICU care	14 (25.9%)	0 (0.0%)	14 (51.9%)	<0.01*
Hospital staying (hrs)
Mean ± SD	32±20	26±17	38±21	0.009^‡
Median (range)	24 (12 to 96)	20 (14 to 96)	32 (12 to 96)

∗Based on Chi-Square test. **Based on Fisher’s exact test. ^‡Based on Mann-Whitney U test.