PPAR𝜹 Agonist GW501516 Inhibits PDGF-Stimulated Pulmonary Arterial Smooth Muscle Cell Function Related to Pathological Vascular Remodeling

Figure 4

Regulation of migration, collagen synthesis, and MCP-1 expression in HPASMCs by GW501516. PDGF-stimulated (a) cell migration, (b) collagen synthesis, and (c) TNF-induced MCP-1 mRNA expression were significantly inhibited by GW501516. Experiments were performed in triplicate and repeated a minimum of three times. ^#𝑃<0.01, ^†𝑃<0.05  versus control; ^∗𝑃<0.05 versus PDGF/TNF-treated cells.

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