Off-Label Use of Ondansetron in Pregnancy in Western Australia
Table 2
Characteristics of children of women dispensed ondansetron any time during pregnancy.
Ondansetron
Nonondansetron = 98,062
OR (95% CI)
%
%
Singleton
241
91.6
94,872
96.7
0.4 (0.2–0.6)
Male
124
47.1
50,295
51.3
0.8 (0.7–1.1)
Stillbirths
<5
1.1
635
0.6
1.8 (0.6–5.5)
APGAR 5 mins < 6*
<5
1.1
576
0.6
2.0 (0.6–6.1)
Birth length 50 cm**
177
67.3
56,100
57.2
1.4 (1.0–1.8)
Birth weight <2500 g**
30
11.4
7,078
7.2
1.3 (0.8–2.2)
POBW below 1
115
47.7
49,708
52.4
0.8 (0.6–1.1)
Resuscitated at birth
125
47.5
42,376
43.2
1.2 (0.9–1.5)
Any birth defect
16
6.1
4,749
4.8
1.3 (0.8–2.1)
Any major birth defect
12
4.6
3,975
4.1
1.1 (0.6–2.0)
Any major birth defect, first trimester exposure***
10
4.7
3,975
4.1
1.2 (0.6–2.2)
POBW: proportion of optimal birth weight.
*Live births only.
**Adjusted for gestational age, smoking during pregnancy, SEIFA, sex, and parity.
***
children of a mother dispensed ondansetron in T1.
