Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 916530, 12 pages
http://dx.doi.org/10.1155/2013/916530
Review Article

The Age-Related Changes in Cartilage and Osteoarthritis

1Department of Orthopaedics, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, Shanxi 030001, China
2Department of Orthopaedics, The Warren Alpert Medical School of Brown University/Rhode Island Hospital, 1 Hoppin Street, Providence, RI 02903, USA

Received 3 April 2013; Revised 7 June 2013; Accepted 9 June 2013

Academic Editor: Vijay K. Goel

Copyright © 2013 YongPing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [58 citations]

The following is the list of published articles that have cited the current article.

  • Muhammed Rauf Ahmed, Azra Mehmood, Fazal-ur-Rehman Bhatti, Shaheen N. Khan, and Sheikh Riazuddin, “Combination of ADMSCs and chondrocytes reduces hypertrophy and improves the functional properties of osteoarthritic cartilage,” Osteoarthritis and Cartilage, 2014. View at Publisher · View at Google Scholar
  • Chih-Wei Chiang, Wei-Chuan Chen, Hsia-Wei Liu, and Chih-Hwa Chen, “Application of Synovial Fluid Mesenchymal Stem Cells: Platelet-rich Plasma Hydrogel for Focal Cartilage Defect,” Journal of Experimental & Clinical Medicine, 2014. View at Publisher · View at Google Scholar
  • Jun Wu, Jun Zhang, and Jin-Bo Liu, “Platelet-rich plasma combined with chondrocytes for construction of injectable tissue-engineered cartilage,” Chinese Journal of Tissue Engineering Research, vol. 18, no. 30, pp. 4764–4770, 2014. View at Publisher · View at Google Scholar
  • Hilde Apold, Haakon E. Meyer, Lars Nordsletten, Ove Furnes, Valborg Baste, and Gunnar B. Flugsrud, “Risk factors for knee replacement due to primary osteoarthritis, a population based, prospective cohort study of 315,495 individuals,” Bmc Musculoskeletal Disorders, vol. 15, 2014. View at Publisher · View at Google Scholar
  • Qingshan Yang, Shifang Guo, Song Wang, Yaowen Qian, Huiping Tai, and Zhixin Chen, “Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte,” Fundamental & Clinical Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Dan Xing, Jin-qian Liang, Yan Li, Jun Lu, Hao-bo Jia, Li-yan Xu, and Xin-long Ma, “Identification of Long Noncoding RNA Associated with Osteoarthritis in Humans,” Orthopaedic Surgery, vol. 6, no. 4, pp. 288–293, 2014. View at Publisher · View at Google Scholar
  • J.M. Fick, M.R.J. Huttu, M.J. Lammi, and R.K. Korhonen, “In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner,” Osteoarthritis and Cartilage, vol. 22, no. 10, pp. 1410–1418, 2014. View at Publisher · View at Google Scholar
  • Ayala Luria, and Constance R. Chu, “Articular Cartilage Changes in Maturing Athletes: New Targets for Joint Rejuvenation,” Sports Health, vol. 6, no. 1, pp. 18–30, 2014. View at Publisher · View at Google Scholar
  • Maria Mesuraca, Olimpio Galasso, Leonardo Guido, Emanuela Chiarella, Stefania Scicchitano, Renaud Vatrinet, Giovanni Morrone, Heather M. Bond, and Giorgio Gasparini, “Expression Profiling and Functional Implications of a Set of Zinc Finger Proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in Primary Osteoarthritic Articular Chondrocytes,” Mediators of Inflammation, vol. 2014, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Amitava Dasgupta, and Kimberly Klein, “Role of Oxidative Stress in Neurodegenerative Diseases and Other Diseases Related to Aging,” Antioxidants in Food, Vitamins and Supplements, pp. 167–184, 2014. View at Publisher · View at Google Scholar
  • Amitava Dasgupta, and Kimberly Kleinpp. 1–344, 2014. View at Publisher · View at Google Scholar
  • Hai Liu, Longhuo Wu, Haiqing Liu, Hongliang Li, Linfu Li, Qilai Cheng, and Hao Huang, “Mitochondrial pathology in Osteoarthritic chondrocytes,” Current Drug Targets, vol. 15, no. 7, pp. 710–719, 2014. View at Publisher · View at Google Scholar
  • Stephen M. Richardson, Gauthaman Kalamegam, Peter N. Pushparaj, Csaba Matta, Adnan Memic, Ali Khademhosseini, Reza Mobasheri, Fabian L. Poletti, Judith A. Hoyland, and Ali Mobasheri, “Mesenchymal Stem Cells in Regenerative Medicine: Focus on Articular Cartilage and Intervertebral Disc Regeneration,” Methods, 2015. View at Publisher · View at Google Scholar
  • Sajjad Ashraf, Byung-Hyun Cha, Jin-Su Kim, Jongchan Ahn, Inbo Han, Hansoo Park, and Soo-Hong Lee, “Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration,” Osteoarthritis and Cartilage, 2015. View at Publisher · View at Google Scholar
  • Yan Zhou, Shi-qing Liu, Hao Peng, Ling Yu, Bin He, and Qi Zhao, “In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis,” International Immunopharmacology, 2015. View at Publisher · View at Google Scholar
  • Lukasz Kuszel, Tomasz Trzeciak, Magdalena Richter, and Malwina Czarny-Ratajczak, “Osteoarthritis and telomere shortening,” Journal Of Applied Genetics, vol. 56, no. 2, pp. 169–176, 2015. View at Publisher · View at Google Scholar
  • Bandna Pal, Helal Endisha, Yue Zhang, and Mohit Kapoor, “mTOR: A Potential Therapeutic Target in Osteoarthritis?,” Drugs in R&D, 2015. View at Publisher · View at Google Scholar
  • Tatsuya Kobayashi, Garyfallia Papaioannou, Fatemeh Mirzamohammadi, Elena Kozehmyakina, Minjie Zhang, Robert Blelloch, and Mark W. Chong, “Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage,” Osteoarthritis and Cartilage, 2015. View at Publisher · View at Google Scholar
  • Maria Victoria Castell, Suzan van der Pas, Angel Otero, Paola Siviero, Elaine Dennison, Michael Denkinger, Nancy Pedersen, Mercedes Sanchez-Martinez, Rocio Queipo, Natasja van Schoor, Sabina Zambon, Mark Edwards, Richard Peter, Laura Schaap, and Dorly Deeg, “Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on OSteoArthritis (EPOSA),” Bmc Musculoskeletal Disorders, vol. 16, 2015. View at Publisher · View at Google Scholar
  • Elena Gabusi, Francesca Paolella, Cristina Manferdini, Laura Gambari, Antonella Schiavinato, and Gina Lisignoli, “Age-independent effects of hyaluronan amide derivative and growth hormone on human osteoarthritic chondrocytes,” Connective Tissue Research, vol. 56, no. 6, pp. 440–451, 2015. View at Publisher · View at Google Scholar
  • Changhe Hou, Ziji Zhang, Zhiqi Zhang, Peihui Wu, Xiaoyi Zhao, Ming Fu, Puyi Sheng, Yan Kang, and Weiming Liao, “Presence and function of microRNA-92a in chondrogenic ATDC5 and adipose-derived mesenchymal stem cells,” Molecular Medicine Reports, vol. 12, no. 4, pp. 4877–4886, 2015. View at Publisher · View at Google Scholar
  • Masoud Hashemi, Parviz Jalili, Shirin Mennati, Alireza Koosha, Ramin Rohanifar, Firouz Madadi, Seyed Sajad Razavi, and Farinaz Taheri, “The Effects of Prolotherapy With Hypertonic Dextrose Versus Prolozone (Intraarticular Ozone) in Patients With Knee Osteoarthritis,” Anesthesiology and Pain Medicine, vol. 5, no. 5, 2015. View at Publisher · View at Google Scholar
  • Priscila Eliane dos Santos Laureano, Kris Daiana Silva Oliveira, Andrea Aparecida de Aro, Laurecir Gomes, Edson Rosa Pimentel, and Marcelo Augusto Marretto Esquisatto, “Structure and composition of arytenoid cartilage of the bullfrog (Lithobates catesbeianus) during maturation and aging,” Micron, vol. 77, pp. 16–24, 2015. View at Publisher · View at Google Scholar
  • Mukundan Attur, Qing Yang, Kohei Shimada, Yuki Tachida, Hiroyuki Nagase, Paolo Mignatti, Lauren Statman, Glyn Palmer, Thorsten Kirsch, Frank Beier, and Steven B. Abramson, “Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13,” Faseb Journal, vol. 29, no. 10, pp. 4107–4121, 2015. View at Publisher · View at Google Scholar
  • Blaine A. Christiansen, Simrit Bhatti, Ramin Goudarzi, and Shahin Emami, “Management of Osteoarthritis with Avocado/Soybean Unsaponifiables,” Cartilage, vol. 6, no. 1, pp. 30–44, 2015. View at Publisher · View at Google Scholar
  • Dawid Bączkowicz, Edyta Majorczyk, and Krzysztof Kręcisz, “Age-Related Impairment of Quality of Joint Motion in Vibroarthrographic Signal Analysis,” BioMed Research International, vol. 2015, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  • Yong Ping Li, Xiao Chun Wei, Peng Cui Li, Chun Wei Chen, Xiao Hu Wang, Qiang Jiao, Dong Ming Wang, Fang Yuan Wei, Jian Zhong Zhang, and Lei Wei, “The Role of miRNAs in Cartilage Homeostasis,” Current Genomics, vol. 16, no. 6, pp. 393–404, 2015. View at Publisher · View at Google Scholar
  • Kaspar Tootsi, Aare Märtson, Mihkel Zilmer, Kaido Paapstel, and Jaak Kals, “Increased arterial stiffness in patients with end-stage osteoarthritis: a case-control study,” BMC Musculoskeletal Disorders, vol. 17, no. 1, 2016. View at Publisher · View at Google Scholar
  • Burin Boonsri, Korakot Nganvongpanit, Waranee Pradit, Kumpanart Soontornvipart, Terdsak Yano, Siriwadee Chomdej, and Siriwan Ongchai, “Prevalence of cartilage erosion in canine patellar luxation and gene expression in affected joints,” Kafkas Universitesi Veteriner Fakultesi Dergisi, vol. 22, no. 4, pp. 561–570, 2016. View at Publisher · View at Google Scholar
  • C.H. Roux, “Cartílago articular normal: anatomía, fisiología, metabolismo y envejecimiento,” EMC - Aparato Locomotor, vol. 49, no. 2, pp. 1–10, 2016. View at Publisher · View at Google Scholar
  • George Coricor, and Rosa Serra, “TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Sally Roberts, Aneka Sowman, Claire Mennan, James R Edwards, Pauline Colombier, Jan H D Rölfing, and Jérôme Guicheux, “Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life,” Acta Orthopaedica, vol. 87, pp. 15–25, 2016. View at Publisher · View at Google Scholar
  • Gustavo Duquepp. 67–73, 2016. View at Publisher · View at Google Scholar
  • Maria Isabel Guillén, Maria Dolores Pérez del Caz, Francisco Gomar, Miguel Angel Castejón, Vicente Mirabet, Maria José Alcaraz, and Julia Platas, “Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes,” Aging, vol. 8, no. 8, pp. 1703–1717, 2016. View at Publisher · View at Google Scholar
  • Tomás Zambrano, Consuelo Arias, Dulcineia S. P. Abdalla, and Luis A. Salazar, “Polyphenol-related epigenetic modifications in osteoarthritis: Current therapeutic perspectives,” Current Pharmaceutical Design, vol. 22, 2016. View at Publisher · View at Google Scholar
  • Guang Li, Ning-qing Huang, Ling-wei Li, and Qi-fa Guo, “Correlation of matrix metalloproteinase 2 and 9 with the early performance of knee osteoarthritis cartilage under MRI,” Chinese Journal of Tissue Engineering Research, vol. 20, no. 37, pp. 5518–5523, 2016. View at Publisher · View at Google Scholar
  • Shankar Lalitha Sridhar, Umut Akalp, Franck J. Vernerey, Stephanie J. Bryant, Stanley Chu, and Stacey C. Skaalure, “Understanding the Spatiotemporal Degradation Behavior of Aggrecanase-Sensitive Poly(ethylene glycol) Hydrogels for Use in Cartilage Tissue Engineering,” Tissue Engineering - Part A, vol. 23, no. 15-16, pp. 795–810, 2017. View at Publisher · View at Google Scholar
  • Agastinose Ronickom Jac Fredo, Thomas Raj Josena, Rajkumar Palaniappan, and Asaithambi Mythili, “Classification Of Normal And Knee Joint Disorder Vibroarthrographic Signals Using Multifractals And Support Vector Machines,” Biomedical Engineering: Applications, Basis and Communications, vol. 29, no. 03, pp. 1750016, 2017. View at Publisher · View at Google Scholar
  • Mandy M. F. Steinbusch, Yongxiang Fang, Peter I. Milner, Peter D. Clegg, David A. Young, Tim J. M. Welting, and Mandy J. Peffers, “Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis,” Scientific Reports, vol. 7, pp. 43558, 2017. View at Publisher · View at Google Scholar
  • Irtyah Merchaoui, Lamia Bouzgarrou, Ahlem Mnasri, Mounir Mghanem, Mohamed Akrout, Jacques Malchaire, and Neila Chaari, “Influence of shift work on the physical work capacity of tunisian nurses: A cross-sectional study in two university hospitals,” Pan African Medical Journal, vol. 26, 2017. View at Publisher · View at Google Scholar
  • Venkata P. Mantripragada, Wesley A. Bova, Cynthia Boehm, Nicolas S. Piuzzi, Nancy A. Obuchowski, Ronald J. Midura, and George F. Muschler, “Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression,” Journal of Orthopaedic Research, 2017. View at Publisher · View at Google Scholar
  • John H Rosenberg, Vikrant Rai, Matthew F Dilisio, Todd D Sekundiak, and Devendra K Agrawal, “Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint.,” Molecular and cellular biochemistry, vol. 436, no. 1-2, pp. 59–69, 2017. View at Publisher · View at Google Scholar
  • Tianlong Wu, Zhongbo Deng, Changchang Yin, Wenzhou Huang, Peng Ao, Jian Li, Libiao Xu, Wenjie Chen, and Xigao Cheng, “Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes,” BioMed Research International, vol. 2017, 2017. View at Publisher · View at Google Scholar
  • Ming Lei, Fei Yu, and De-Ming Xiao, “Clinical manifestations of osteoarthritis and the role of silent information regulation 1 in the pathogenesis of osteoarthritis,” Chinese Journal of Tissue Engineering Research, vol. 21, no. 12, pp. 1933–1939, 2017. View at Publisher · View at Google Scholar
  • Katarzyna Kulcenty, Tomasz Trzeciak, Magdalena Richter, Michal Stefan Lach, Karolina Jankowska, and Wiktoria Maria Suchorska, “Effect of cellular mass on chondrogenic differentiation during embryoid body formation,” Molecular Medicine Reports, vol. 18, no. 3, pp. 2705–2714, 2018. View at Publisher · View at Google Scholar
  • Ekaterina Medvedeva, Ekaterina Grebenik, Svetlana Gornostaeva, Vladimir Telpuhov, Aleksey Lychagin, Peter Timashev, and Andrei Chagin, “Repair of Damaged Articular Cartilage: Current Approaches and Future Directions,” International Journal of Molecular Sciences, vol. 19, no. 8, pp. 2366, 2018. View at Publisher · View at Google Scholar
  • Chi Zhang, Yukai Wang, Congfeng Luo, Yulin Zhan, Wei Zhang, Peichun Hsu, Biao Zhong, Shang Guo, and Changqing Zhang, “MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway,” Cellular Physiology and Biochemistry, vol. 48, no. 3, pp. 1304–1316, 2018. View at Publisher · View at Google Scholar
  • Jolanta Zwolińska, Aneta Weres, and Justyna Wyszyńska, “One-Year Follow-Up of Spa Treatment in Older Patients with Osteoarthritis: A Prospective, Single Group Study,” BioMed Research International, vol. 2018, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • Arash Babaei-Ghazani, Saeedeh Najarzadeh, Korosh Mansoori, Bijan Forogh, Seyed Pezhman Madani, Safoora Ebadi, Hamid Reza Fadavi, and Bina Eftekharsadat, “The effects of ultrasound-guided corticosteroid injection compared to oxygen–ozone (O2–O3) injection in patients with knee osteoarthritis: a randomized controlled trial,” Clinical Rheumatology, 2018. View at Publisher · View at Google Scholar
  • Dawei Zhang, Gang Zhang, Zongyu Li, and Bingsheng Li, “Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation,” Experimental Biology and Medicine, pp. 153537021875795, 2018. View at Publisher · View at Google Scholar
  • Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek, Adam Osowski, and Joanna Wojtkiewicz, “Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy,” International Journal of Molecular Sciences, vol. 19, no. 2, pp. 623, 2018. View at Publisher · View at Google Scholar
  • Santiago Rodrigues-Manica, José Marona, Tiago Costa, Carina Lopes, João Gomes, Sandra Falcão, and Jaime Branco, “Ozone therapy in knee osteoarthritis: A systematic review,” Acta Medica Portuguesa, vol. 31, no. 10, pp. 576–580, 2018. View at Publisher · View at Google Scholar
  • Andreas Goutas, Christina Syrrou, Ioanna Papathanasiou, Aspasia Tsezou, and Varvara Trachana, “The autophagic response to oxidative stress in osteoarthritic chondrocytes is deregulated,” Free Radical Biology and Medicine, vol. 126, pp. 122–132, 2018. View at Publisher · View at Google Scholar
  • Zhi-Jiang Sun, and Ya-Yi Xia, “Autophagy plays a protective role in advanced glycation end products-induced apoptosis of chondrocytes via regulation of tumor necrosis factor-?, nuclear factor-?B and reactive oxygen species,” Asian Pacific Journal of Tropical Medicine, vol. 11, no. 1, pp. 73–77, 2018. View at Publisher · View at Google Scholar
  • Daas Selim, Sahli Hana, Ben Tekaya Aicha, Mahmoud Ines, and Tekaya Rawdha, “Clinical and radiographic features of knee osteoarthritis of elderly patients,” Current Rheumatology Reviews, vol. 14, no. 2, pp. 181–187, 2018. View at Publisher · View at Google Scholar
  • Satoru Yamaguchi, Kaoru Yamamoto, and Hidetsugu Tsujigiwa, “Analysis of Demineralized Mammalian Bone Tissue by Fourier Transform Infrared Microscopy,” Journal of Hard Tissue Biology, vol. 27, no. 1, pp. 59–64, 2018. View at Publisher · View at Google Scholar
  • Valeria Graceffa, and Dimitrios I. Zeugolis, “Macromolecular crowding as a means to assess the effectiveness of chondrogenic media,” Journal of Tissue Engineering and Regenerative Medicine, 2018. View at Publisher · View at Google Scholar
  • Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R. Wang, Peter D. Wang, and Win-Ping Deng, “Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review,” Stem Cells International, vol. 2018, pp. 1–13, 2018. View at Publisher · View at Google Scholar