Synthesis of a Novel Thiazolidinedione and Evaluation of Its Modulatory Effect on IFN-<i>γ</i>, IL-6, IL-17A, and IL-22 Production in PBMCs from Rheumatoid Arthritis Patients

<table>Evaluation of cytokines release inhibition by TM17 compound in PBMC culture from healthly donor. (a) TM17 in 100 <i>μ</i>M as well as positive control (methylprednisolone) was able to decrease significantly INF-<i>γ</i> levels. The same pattern was observed for IL-6 (b) and IL-17A (c). <svg height="13.95" id="M20" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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BioMed Research International

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Figure 4

Figure 4: Synthesis of a Novel Thiazolidinedione and Evaluation of Its Modulatory Effect on IFN-<i>γ</i>, IL-6, IL-17A, and IL-22 Production in PBMCs from Rheumatoid Arthritis Patients 

Figure 4 | Synthesis of a Novel Thiazolidinedione and Evaluation of Its Modulatory Effect on IFN-γ, IL-6, IL-17A, and IL-22 Production in PBMCs from Rheumatoid Arthritis Patients 