BioMed Research International / 2013 / Article / Tab 1

Review Article

Stem Cell Therapy in Bladder Dysfunction: Where Are We? And Where Do We Have to Go?

Table 1

Studies about stem cell therapy for bladder dysfunction.

SourceMechanism of bladder dysfunctionStem cellAnimalTransplantation routeTracking of stem cellBladder activityFunctional studySmooth muscle differentiationRemarks

Lee et al. [19]BOOHuman BM-MSCRatDirect transplantation into bladderIron oxide nanoparticleOveractivityUDS done: improvement of ICI, MVP, and RUNoIn vivo MRI examination for tracking MSC

Song et al. [20]BOOHuman BM-MSCRatDirect transplantation into bladderNoneOveractivityUDS done: improvement of ICI and MVPYesTransfection of human HGF gene into MSC

Woo et al. [21]BOOMice BM-MSCMiceIntravenous injectionNoneOveractivityUDS done: improvement of capacity and complianceNoExpression of chemokine CCL2

Tanaka et al.
[36]
BOOBMD cellMiceDirect transplantation into BMGFP labelingOveractivityUDS done:
improvement of compliance and capacity
NoBOO was made by periurethral collagen injection, radiation was induced, and CCL2 induction increased.

Nishijima et al. [39]BOOBM cellRatDirect transplantation into bladderGFP labelingUnderactivityUDS done: improvement of ICI and RUYesUnderactive model was created

Chen et al. [40]Chronic ischemia by bilateral iliac artery ligationBM-MSCRatIntra-arterial injectionBrdU labelingUnderactivityUDS done: improvement of ICINoDoxazosin mesylate was intragastrically administrated

Huang et al.
[41]
Chronic ischemia by hyperlipidemiaADSCRatDirect transplantation into bladder/intravenous injectionEdU labelingOveractivityUDS done: improvement of ICI and VVYesDirect transplanted group showed better differentiation and better functional improvement

Zhang et al. [46]DiabetesADSCRatDirect transplantation into bladder/intravenous injectionEdU labelingOveractivity. underactivityUDS done: improvement of ICI and VVNoDirect transplanted group showed better differentiation and better functional improvement

De Coppi et al. [54]CryoinjuredBM-MSC and AF-MSCRatDirect transplantation into bladderGFP labelingN/AN/AYesCell fusion in vitro

Huard et al. [56]CryoinjuredMuscle-derived cellMiceDirect transplantation into bladderLacZ stainingUnderactivityContractility test using muscle strip done: improvement of contractilityYesEx vivo gene transfer using β-galactosidase

Sakuma et al. [57]CryoinjuredAdipocyte derived fat cellMiceDirect transplantation into bladderGFP labelingUnderactivityN/AYesTGF-β signaling for smooth muscle differentiation

Nitta et al. [10]Pelvic nerve injuredSk-MSCRatDamaged nerve lesionGFP labelingUnderactivityUDS done under electrical stimulation: improvement of IVPYesAutologous and heterologous models were experimented together

Kwon et al. [11]Pelvic nerve injuredMuscle-derived cellRatDamaged nerve lesionEnkephalin stainingUnderactivityUDS done under electrical stimulation: improvement of IVPNoAutograft

Mitsui et al.
[49]
SCINeural stem cellRatDamaged cord lesionBrdU labelingOveractivityUDS done: improvement of VV and VPNoNo difference in the incidence of detrusor overactivity

Temeltas et al. [52]SCIBone marrow stromal cellRatDamaged cord lesionE-NACM stainingOveractivityUDS done: improvement of VV, RU and VPN/AGlial restricted precursor was also treated

Hu et al. [53]SCIBone marrow stromal cellRatIntravenous injectionBrdU labelingOveractivityUDS done: improvement of compliance and capacityN/AExternal urethral sphincter activity was checked

BOO: bladder outlet obstruction; SCI: spinal cord injury; MSC: mesenchymal stem cell; BMD: bone marrow derived cell; ADSC: adipose derived stem cell; AF-MSC: amniotic fluid derived mesenchymal stem cell; Sk-MSC: Skeletal muscle derived mesenchymal stem cell; UDS: urodynamic study; ICI: inter-contraction interval; MVP: maximal voiding pressure; RU: residual urine; VV: voided volume; VP: voiding pressure; IVP: intravesical pressure; GFP: green fluorescent protein.

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