Kidney Dosimetry in ¹⁷⁷Lu and ⁹⁰Y Peptide Receptor Radionuclide Therapy: Influence of Image Timing, Time-Activity Integration Method, and Risk Factors

Table 3

Ratio of 𝑎 computed with BI, MN, MNfix, TRexp methods with best 𝑎 determined by means of 𝐹-test and visual choice. “6 h-point excluded” and “3 d-point excluded” mean that fitting was conducted skipping the 6 h and the 3 d point, respectively. The shared 𝜆 (MNfix) was only computed in the 5-point case.

Mean ± 1SD	𝑎 ratios
		^177Lu peptides			^90Y peptides
	5 points	6 h point excluded	3 d point excluded	5 points	6 h point excluded	3 d point excluded
F-test
BI/FT	1.10±0.29	1.09±0.29	1.08±0.21	1.04±0.10	1.03±0.09	1.04±0.09
MN/FT	1.05±0.16	1.04±0.17	1.09±0.31	1.02±0.06	1.03±0.07	1.03±0.13
MNfix/FT	1.00±0.18	Na	Na	0.99±0.10	Na	Na
TRexp/FT	0.90±0.30	0.91±0.31	0.78±0.18	1.07±0.22	1.09±0.22	0.97±0.16
Visual
BI/VIS	1.02±0.07	1.02±0.19	1.03±0.18	1.01±0.05	1.00±0.06	1.01±0.09
MN/VIS	1.02±0.22	1.00±0.23	1.05±0.36	1.00±0.08	1.00±0.09	1.01±0.16
MNfix/VIS	0.97±0.20	Na	Na	0.97±0.11	Na	Na
TRexp/VIS	0.88±0.24	0.89±0.24	0.72±0.16	1.06±0.20	1.07±0.21	0.90±0.14