In Vivo Imaging of Leukocyte Recruitment to the Atheroprone Femoral Artery Reveals Anti-Inflammatory Effects of Rosuvastatin
Figure 2
Effect of rosuvastatin on leukocyte recruitment to the femoral artery of ApoE−/− mice. ApoE−/− mice were administered HF with rosuvastatin for 6 weeks of age to 6 weeks. (a) Captured image of leukocyte interaction in a femoral artery treated with vehicle (left) and rosuvastatin (right). The number of adherent leukocytes was quantified by image analysis software. (b) Effect of rosuvastatin on expression levels of VCAM-1 and ICAM-1 (*). (c) Microphotographs of aortas in ApoE−/− mice treated with vehicle or rosuvastatin and stained by DHE (×200). (d) Effect of rosuvastatin on expression levels of gp91-phox and p22-phox in aortas of ApoE−/− mice (*). (e) Total cholesterol level and triglyceride level in plasma of HF-fed ApoE−/− mice treated with vehicle or rosuvastatin.
