Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013 (2013), Article ID 963248, 14 pages
http://dx.doi.org/10.1155/2013/963248
Review Article

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity

1Department of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South Africa
2Department of Public Health Medicine, University of KwaZulu-Natal, Howard College Campus, Durban 4001, South Africa

Received 7 October 2012; Accepted 4 February 2013

Academic Editor: Paul W. Doetsch

Copyright © 2013 K. N. Venugopala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.