Acute Toxicity and Gastroprotective Role of M. pruriens in Ethanol-Induced Gastric Mucosal Injuries in Rats
Figure 2
Effects of M. pruriens extract on macroscopic appearance of the gastric mucosa. The negative control group and the extract control group show no injuries to the gastric mucosa ((a) and (b)). Severe injuries are observed in the gastric mucosa of the ulcer control group. Ethanol produced extensive visible hemorrhagic necrosis of the gastric mucosa (c). The reference control group, pretreated with omeprazole (20 mg/kg), shows mild injuries to the gastric mucosa (d). In the experimental groups, rats pretreated with 62.5 mg/kg of the extract shows moderate injuries in the gastric mucosa (e); in the pretreatment with 125 mg/kg of the extract, more moderate injuries are observed in the gastric mucosa (f); rats pretreated with 250 show mild injuries in the mucosa (g); pretreatment with 500 mg/kg of the extract shows no injuries to the gastric mucosa; instead, flattening of the gastric mucosa is observed (h).
