Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury
Figure 7
Neurofilament 200 kDa immunoreactivity in the motor and sensory areas of cerebral cortex of the different animal groups investigated. (A) Control Sham-operated WKY rats, (B) control Sham-operated SHRs, (C) control CCI SHRs, (D) CCI SHRs treated with ()-thioctic acid 250 μmol/kg/day, (E) CCI SHRs treated with ()-thioctic acid 125 μmol/kg/day, (F) CCI SHRs treated with (+)-thioctic acid 125 μmol/kg/day, (G) CCI SHRs treated with (−)-thioctic acid 125 μmol/kg/day, and (H) CCI SHRs treated with pregabalin 300 μmol/kg/day (H). Values are expressed in arbitrary units calculated microdensitometrically as detailed in Section 2. Data are the mean ± SE. * versus WKY control rats; ** versus SHR Sham-operated control rats; *** versus control CCI SHR.
