Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models
Figure 1
Comparison of mutation bias and minimal contrasts for all 2–4 bp mutations contexts in H. sapiens and M. musculus. Each dot represents a mutation context. The -axis of each plot represents the contexts minimal contrast values, and the -axis represents the contexts mutation bias. The values of mutation bias and minimal contrast are given for H. sapiens (plots (a) and (c)) or M. musculus (plots (b) and (d)). The color scheme indicates the difference between mutation biases (plots (a) and (b)) and minimal contrasts (plots (c) and (d)). Thus red dots on (a) and (c) represent contexts that are hypermutable in H. sapiens compared to M. musculus, while green dots represent contexts that are hypermutable in M. musculus compared to H. sapiens. This color scheme is reversed for (b) and (d). Note that many dots are situated in pairs; this is because complimentary mutation contexts have very similar mutation bias and minimal contrast values.
