Comparative Analysis of Context-Dependent Mutagenesis Using Human and Mouse Models

Table 2

Top 5 40 bp mutation contexts by minimal contrast in H. sapiens and M. musculus. The provided subcontext is the context with the most similar to the contexts mutation bias value and is the one used for the minimal contrast calculation. Also reverse contexts are provided (contexts with the reverse mutation) with their minimal contrast and mutation bias values.

Context; {mut∣pos, W }	Minimal contrast	Mutation bias	Subcontext; {mut∣pos′, W′}	Reverse context	Minimal contrast	Mutation bias
H. sapiens
{T > C∣2, ATTG}	2.12	3.46	{T > C∣1, TTG}	{C > T∣2, ACTG}	0.86	0.75
{A > C∣1, ACAA}	1.89	3.43	{A > C∣1, ACA}	{C > A∣1, CCAA}	1.01	1.20
{T > C∣2, ATAG}	1.78	3.29	{T > C∣2, ATA}	{C > T∣2, ACAG}	0.95	0.81
{G > C∣3, TCGA}	1.43	1.98	{G > C∣3, TCG}	{C > G∣3, TCCA}	0.59	0.37
{T > G∣4, CGGT}	1.42	2.64	{T > G∣3, GGT}	{G > T∣4, CGGG}	0.84	0.84
M. musculus
{G > T∣1, GCGA}	1.83	3.00	{G > T∣1, GCG}	{T > G∣1, TCGA}	1.19	1.19
{T > A∣3, TTTA}	1.60	2.31	{T > A∣2, TTA}	{A > T∣3, TTAA}	1.47	2.55
{T > C∣2, ATTG}	1.59	2.25	{T > C∣2, AT}	{C > T∣2, ACTG}	1.01	1.01
{G > A∣4, CGCG}	1.54	1.54	{G > A∣1, G}	{A > G∣4, CGCA}	0.68	0.68
{T > A∣2, TTAA}	1.47	2.55	{T > A∣1, TAA}	{A > T∣2, TAAA}	1.60	2.31