Research Article

Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats

Figure 5

Effect of carvedilol (1 and 10 mg/kg/day) on glomerular basement membrane and Bowman’s capsule of streptozotocin-induced early diabetic nephropathy in rats (PAS 100x). (a) Kidney tissue of nondiabetic rat showing normal thickness of glomerular basement membrane (red arrow), Bowman’s capsule (blue arrow), proximal convoluted tubule (PC) (green arrow), and distal convoluted tubule (DT) (black arrow). Notice the brush border of PC (asterisks). (b) Kidney tissue of diabetic rat; notice increase in the thickness of glomerular basement membrane (arrows) and nodular substance stained positive with PAS (arrowhead). Notice loss of brush border of PC (asterisk). (c) Kidney tissue after treatment with 1 mg carvedilol; the histological features are relatively improved compared to nontreated diabetic group. Glomerular basement membrane is still thicker than normal (red arrow) and some of PC retained their brush border (arrowhead), while others did not (asterisk). Basement membrane of Bowman’s capsule (blue arrow), PC (green arrow), and DC (black arrow) is still thick. (d) Kidney tissue from diabetic rat treated with 10 mg carvedilol; basement membrane of glomerular capillaries (red arrow), Bowman’s capsule (blue arrow), PC (green arrow), and DC (black arrow) is of normal thickness. Notice normal brush border of PC (asterisks).
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