Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 123010, 8 pages
http://dx.doi.org/10.1155/2014/123010
Review Article

NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review

Laboratório de Biologia Celular, Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, Rua Sarmento Leite, No. 245, 90050-170 Porto Alegre, RS, Brazil

Received 26 February 2014; Accepted 18 May 2014; Published 23 June 2014

Academic Editor: Zhen Chen

Copyright © 2014 Paula Andreghetto Bracco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. P. Chadwick and A.-M. Frischauf, “The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster,” Genomics, vol. 50, no. 3, pp. 357–367, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. J. J. Mulero, G. Yeung, S. T. Nelken, and J. E. Ford, “CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates,” Journal of Biological Chemistry, vol. 274, no. 29, pp. 20064–20067, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. J. J. Mulero, G. Yeung, S. T. Nelken, J. M. Bright, D. W. McGowan, and J. E. Ford, “Biochemical characterization of CD39L4,” Biochemistry, vol. 39, no. 42, pp. 12924–12928, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. J. G. Páez, J. A. Recio, A. Rouzaut, and V. Notario, “Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene,” International Journal of Oncology, vol. 19, no. 6, pp. 1249–1254, 2001. View at Google Scholar · View at Scopus
  5. J. A. Recio, N. Zambrano, L. de La Pena et al., “cDNA isolation, expression, and chromosomal localization of the mouse pcph proto-oncogene,” Molecular Carcinogenesis, vol. 26, no. 2, pp. 130–136, 1999. View at Google Scholar
  6. J. A. Velasco, R. Castro, M. A. Avila et al., “cph, a novel oncogene which cooperates with H-ras in the transformation of NIH3T3 fibroblasts,” Oncogene, vol. 9, no. 7, pp. 2065–2069, 1994. View at Google Scholar · View at Scopus
  7. J. A. Velasco, M. A. Avila, and V. Notario, “The product of the cph oncogene is a truncated, nucleotide-binding protein that enhances cellular survival to stress,” Oncogene, vol. 18, no. 3, pp. 689–701, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. J. A. Recio, J. G. Páez, B. Maskeri, M. Loveland, J. A. Velasco, and V. Notario, “Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with ras in activating extracellular signal-regulated kinase ERK1,” Cancer Research, vol. 60, no. 6, pp. 1720–1728, 2000. View at Google Scholar · View at Scopus
  9. C. M. MacCarthy and V. Notario, “The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family,” International Journal of Oncology, vol. 43, no. 4, pp. 1244–1252, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. O. M. Tirado, S. Mateo-Lozano, S. Sanders, L. E. Dettin, and V. Notario, “The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation,” Cancer Research, vol. 63, no. 19, pp. 6290–6298, 2003. View at Google Scholar · View at Scopus
  11. R. Read, G. Hansen, J. Kramer, R. Finch, L. Li, and P. Vogel, “Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest,” Veterinary Pathology, vol. 46, no. 3, pp. 491–504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Rouzaut, J. A. Recio, and V. Notario, “Expression of the protein product of the PCPH proto-oncogene in human tumor cell lines,” Radiation Research, vol. 155, no. 1, pp. 181–187, 2001. View at Google Scholar · View at Scopus
  13. M. Solanas, E. Escrich, A. Rouzaut, I. Costa, A. Martínez, and V. Notario, “Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7, 12-dimethylbenz[a]anthracene,” Molecular Carcinogenesis, vol. 33, no. 4, pp. 219–227, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Beckenkamp, D. B. Santana, A. N. Bruno et al., “Ectonucleotidase expression profile and activity in human cervical cancer cell lines,” Biochemistry and Cell Biology, vol. 92, no. 2, pp. 95–104, 2014. View at Publisher · View at Google Scholar
  15. S. Zadran, A. Amighi, E. Otiniano, K. Wong, and H. Zadran, “ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme,” Tumour Biology, vol. 33, no. 6, pp. 2411–2421, 2012. View at Google Scholar · View at Scopus
  16. J. Villar, M. I. Arenas, C. M. MacCarthy, M. J. Blánquez, O. M. Tirado, and V. Notario, “PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase Cδ-dependent mechanism,” Cancer Research, vol. 67, no. 22, pp. 10859–10868, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Regadera, M. J. Blánquez, P. González-Peramato et al., “PCPH expression is an early event in the development of testicular germ cell tumors,” International Journal of Oncology, vol. 28, no. 3, pp. 595–604, 2006. View at Google Scholar · View at Scopus
  18. M. J. Blánquez, M. I. Arenas, I. Conde, O. M. Tirado, R. Paniagua, and V. Notario, “Deregulated expression of the PCPH proto-oncogene in human breast cancers,” International Journal of Oncology, vol. 25, no. 4, pp. 821–830, 2004. View at Google Scholar · View at Scopus
  19. M. J. Blánquez, J. Regadera, J. Mariño, R. E. Newman, and V. Notario, “Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia,” Molecular Carcinogenesis, vol. 35, no. 4, pp. 186–195, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Mikula, T. Rubel, J. Karczmarski, K. Goryca, M. Dadlez, and J. Ostrowski, “Integrating proteomic and transcriptomic high-throughput surveys for search of new biomarkers of colon tumors,” Functional and Integrative Genomics, vol. 11, no. 2, pp. 215–224, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. A. Recio, J. G. Páez, S. Sanders, T. Kawakami, and V. Notario, “Partial depletion of intracellular ATP mediates the stress-survival function of the PCPH oncoprotein,” Cancer Research, vol. 62, no. 9, pp. 2690–2694, 2002. View at Google Scholar · View at Scopus
  22. J. Villar, H. S. Quadri, I. Song, Y. Tomita, O. M. Tirado, and V. Notario, “PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Cα-mediated Bcl-2 stabilization,” Cancer Research, vol. 69, no. 1, pp. 102–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Fang, Z. Shen, S. Huang et al., “The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway,” Cell, vol. 143, no. 5, pp. 711–724, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Shen, S. Huang, M. Fang, and X. Wang, “ENTPD5, an endoplasmic reticulum udpase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells,” Cold Spring Harbor Symposia on Quantitative Biology, vol. 76, pp. 217–223, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. N. L. Curry, M. Mino-Kenudson, T. G. Oliver et al., “Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction,” Cancer Discovery, vol. 3, no. 8, pp. 908–921, 2013. View at Publisher · View at Google Scholar · View at Scopus