Review Article

NTPDase5/PCPH as a New Target in Highly Aggressive Tumors: A Systematic Review

Table 2

NTPDase5/mt-PCPH profile expression in clinical samples.

Author;
year
Tissue studyMethodsSampling sizeControl groupNTPDase5 expressionmt-PCPH expression

Zadran et al., 2012 [15]Primary glioblastoma multiforme (GBMs)Tissue microarrays, IHC, and WB140 patientsAdjacent normal brainElevated levels were observed in GBM cores when compared to adjacent normal tissuesNot described
Mikula et al., 2010 [20]Adenocarcinomas and colonic adenomasMass spectrometry and qRT-PCR 5 adenocarcinomas; 12 colonic adenomas; 4 normal mucosasNormal mucosaContinuously downregulated in a progression from normal mucosa to adenocarcinoma Not described
Villar et al., 2007 [16]Prostate normal, hyperplasic, and tumor cellsIHC63 patientsNormal human prostateNot detected in normal prostate, detected slightly in HPB, and elevated in PIN and prostate carcinoma (samples with a Gleason score less than 7 present lower levels) Not described
Regadera et al., 2006 [17]Testicular tumorsIHC54 patientsNormal testicular tissueIncreased expression in testicular tumors relative to normal tissue; present in well-differentiated squamous epithelia and lost in dedifferentiated squamous cellsNot described
Blánquez et al., 2002 [19]Laryngeal mild, moderate, and severe stages dysplastic lesionsIHC59 patientsNormal laryngeal mucosaExpressed at lower levels in severe than in mild dysplastic cases and at much lower levels than in the normal tissueNot described
Blánquez et al., 2004 [18]Human breast tumorsIHC and WB54 patientsNormal human breast samplesUndetectable in normal and benign samples and increase in carcinoma in situ and more strongly in invasive ductal and lobular carcinomaAbsent in benign human breast and low molecular weight polypeptides in ductal and lobular carcinoma
Solanas et al., 2002 [13]Rat mammary benign and malignant tumors inducedIHC and WB35 malignant tumors; 19 benign tumorsNormal rat mammary glandTumor samples showed higher levels and were more expressed in the malignant tumorsTumor samples showed decrease in the mt-NTPDase5 expression when compared with the normal tissue

Legend: HPB: hyperplasia prostate benign; PIN: prostatic intraepithelial neoplasia; IHC: immunohistochemistry; WB: Western blot.