Phosphoproteomic Analysis of Gossypol-Induced Apoptosis in Ovarian Cancer Cell Line, HOC1a

Table 1

Gossypol-induced changes of phosphoproteins in HOC1a cells.

IPI accession	Protein name	Peptide sequence	Control	Gossypol-treated
IPI00002186	Brefeldin A-inhibited guanine nucleotide-exchange protein 2	GSSLSGTDDGAQEVVKDILEDVVTSAIK	+	++
IPI00008529	60S acidic ribosomal protein P2	KEESEESDDDMGFGLFD		+
IPI00237884	Isoform 1 of A-kinase anchor protein 12	SAESPTSPVTSETGSTFK	+	++
IPI00185919	Isoform 1 of La-related protein 1	GLSASLPDLDSENWIEVK		+
IPI00015953	Isoform 1 of nucleolar RNA helicase 2	NEEPSEEEIDAPKPK		+
IPI00102752	Isoform 1 of putative RNA-binding protein 15	SLSPGGAALGYR		+
IPI00451401	Isoform 2 of triosephosphate isomerase	KQSLGELIGTLNAAK		+
IPI00293312	Isoform 2 of zinc finger CCCH domain-containing protein 18	LGVSVSPSR		+
IPI00023748	Nascent polypeptide-associated complex subunit alpha	VQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVK	+	++
IPI00604756	Nuclear receptor-binding protein	TPTPEPAEVETR		+
IPI00010471	Plastin-2	GSVSDEEMMELR	+	++
IPI00015029	Prostaglandin E synthase 3	DWEDDSDEDMSNFDR		+
IPI00012442	Ras GTPase-activating protein-binding protein 1	SSSPAPADIAQTVQEDLR	+	++
IPI00008708	Ribosomal L1 domain-containing protein 1	ATNESEDEIPQLVPIGK		+
IPI00029601	Src substrate cortactin	LPSSPVYEDAASFK; TQTPPVSPAPQPTEER; TQTPPVSPAPQPTEER		+
IPI00045051	Transcriptional activator protein Pur-beta	DSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPR		+
IPI00009326	Yes-associated protein beta	GDSETDLEALFNAVMNPK	+	++
IPI00844578	ATP-dependent RNA helicase A	SEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALK	+
IPI00010463	GTP-binding protein 1	GLGPPSPPAPPR	+
IPI00009505	Isoform 1 of beta-2-syntrophin	GLGPPSPPAPPR	+
IPI00216049	Isoform 1 of heterogeneous nuclear ribonucleoprotein K	METEQPEETFPNTETNGEFGK	+
IPI00019848	Isoform 1 of host cell factor 1	SQCQTRQTSATSTTMTVMATGAPCSAGPLLGPSMAREPGGR	+
IPI00782992	Isoform 1 of serine/arginine repetitive matrix protein 2	MALPPQEDATASPPR; THTTALAGRSPSPASGR	+
IPI00026466	Isoform 2 of nipped-B-like protein	AITSLLGGGSPK	+
IPI00150057	Isoform 2 of SWI/SNF complex subunit SMARCC2	DMDEPSPVPNVEEVTLPK	+
IPI00165041	Isoform 6 of treacle protein	TSQVGAASAPAKESPR	+
IPI00006122	Isoform MEA6 of cutaneous T-cell lymphoma-associated antigen 5	AFLSPPTLLEGPLR	+
IPI00164672	mRNA-decapping enzyme 1A	HAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPR	+
IPI00103483	Negative elongation factor B	KPSPAQAAETPALELPLPSVPAPAPL	+
IPI00021812	Neuroblast differentiation-associated protein AHNAK	FKAEAPLPSPK	++	+

⁺Identified phosphorylated proteins. ⁺⁺More than 2-fold difference with respect to control.