Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy
Figure 4
Effect of losartan, atorvastatin, or farnesyl transferase inhibitor (FTI) administration on renal alpha-smooth muscle actin (α-SMA) expression detected by immunohistochemistry in UUO mice. Representative interstitial sections from nonobstructed (NO) and obstructed (O) kidneys of UUO untreated control mice ((a) and (b)) and UUO mice treated with losartan ((c) and (d)), atorvastatin ((e) and (f)) or FTI ((g) and (h)). Black bar indicates 100 microns in all panels.
