Endothelial Function in a Mouse Model of Myeloperoxidase Deficiency

Figure 6

Concentration-response relation for Ach in saphenous arteries in the absence (a) and presence (b) of L-NAME and indomethacin (showing the EDHF response). Vessels from MPO^−/− responded less than vessels from wild-type: EC₅₀ was in (a) control −7.95±0.045, MPO^−/−  −7.65±0.041 (𝑃<0.001) and in (b) control −7.19±0.100, MPO^−/−  −6.98±0.16 (𝑃<0.001).

(a)

(b)