BioMed Research International / 2014 / Article / Tab 1

Clinical Study

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Table 1

Clinical and demographic characteristics of healthy subjects and relapsing-remitting multiple sclerosis (RRMS) patients regarding optic neuritis (ON) antecedent. Differences were tested using generalized estimating equations accounting for sex, age, and within-patient intereye correlation.

Healthy subjectsRRMSON eyesNon-ON eyes (healthy versus RRMS) (healthy versus ON eyes) (healthy versus non-ON eyes) (ON versus non-ON eyes)
Mean ± SD

Age (years)0.0770.0080.0770.302
Female (%)40 (57%)44 (63%)14 (78%)30 (58%)0.3870.6270.3630.552
LogMAR BCVA0.0060.0230.1150.083
EDSS scoreN/AN/AN/AN/A0.873
Years since diagnosisN/AN/AN/AN/A0.754
MD (in dB)N/AN/AN/AN/A<0.001
Average pRNFL (Sp; in m)<0.001<0.001<0.001<0.001
Temporal pRNFL (Sp; in m)<0.001<0.001<0.001<0.001
PMB pRNFL (Sp; in m)<0.001<0.001<0.001<0.001
Average pRNFL (Ci; in m)<0.001<0.001<0.001<0.001
Temporal pRNFL (Ci; in m)<0.001<0.001<0.001<0.001
Average GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Minimum GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Superior GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Superonasal GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Inferonasal GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Inferior GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Inferotemporal GCIPL (Ci; in m)<0.001<0.001<0.001<0.001
Superotemporal GCIPL (Ci; in m)<0.001<0.001<0.001<0.001

SD: standard deviation; BCVA: best corrected visual acuity; EDSS: Expanded Disability Status Scale; MD: 24-2 SITA Standard Visual Field Mean Deviation; pRNFL: peripapillary retinal nerve fiber layer; Sp: Spectralis OCT; PMB: papillomacular bundle; Ci: Cirrus OCT; GCIPL: ganglion cell and inner plexiform layers.