BioMed Research International / 2014 / Article / Tab 2

Clinical Study

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Table 2

Number of eyes (and percentage) with abnormal results (yellow or red color-coded) in healthy and relapsing-remitting multiple sclerosis (RRMS) patients and according to optic neuritis (ON) antecedent. Statistical significance of associations was tested using generalized estimating equations accounting for sex, age, and within-patient intereye correlation.

Abnormal resultHealthyRRMSON eyesNon-ON eyes (healthy versus RRMS) (healthy versus ON eyes) (healthy versus non-ON eyes) (ON versus non-ON eyes)

Average pRNFL (Sp)5 (3.6)49 (35.0)20 (55.6)29 (27.9)<0.001<0.001<0.001<0.001
Temporal pRNFL (Sp)5 (3.6)65 (46.4)22 (61.1)43 (41.3)<0.001<0.001<0.001<0.001
PMB pRNFL (Sp)4 (2.9)43 (30.7)17 (47.22)26 (25.0)<0.001<0.001<0.0010.012
Average pRNFL (Ci)9 (6.4)46 (32.9)19 (52.8)27 (26.0)<0.001<0.0010.0010.001
Temporal pRNFL (Ci)2 (1.4)49 (35.0)24 (66.7)25 (24.0)<0.001<0.001<0.001<0.001
Average GCIPL (Ci)8 (5.7)65 (46.4)25 (69.4)40 (38.5)<0.001<0.001<0.001<0.001
Minimum GCIPL (Ci)7 (5.0)67 (47.9)28 (77.8)39 (37.5)<0.001<0.001<0.001<0.001
Superior GCIPL (Ci)8 (5.7)63 (45.0)26 (72.2)37 (35.6)<0.001<0.001<0.001<0.001
Superonasal GCIPL (Ci)4 (2.9)66 (47.1)26 (72.2)40 (38.5)<0.001<0.001<0.001<0.001
Inferonasal GCIPL (Ci)4 (2.9)58 (41.4)27 (75.0)31 (29.8)<0.001<0.001<0.001<0.001
Inferior GCIPL (Ci)2 (1.4)50 (35.7)23 (63.9)27 (26.0)<0.001<0.001<0.001<0.001
Inferotemporal GCIPL (Ci)6 (4.3)55 (39.3)22 (61.1)33 (31.7)<0.001<0.001<0.0010.002
Superotemporal GCIPL (Ci)12 (8.9)64 (45.7)25 (69.4)39 (37.5)<0.001<0.001<0.001<0.001

pRNFL: peripapillary retinal nerve fiber layer; Sp: Spectralis OCT; PMB: papillomacular bundle; Ci: Cirrus OCT; GCIPL: ganglion cell and inner plexiform layers.