BioMed Research International / 2014 / Article / Tab 3

Clinical Study

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Table 3

Estimated sensitivity and specificity of different optic coherence tomography measures for retinal thickness changes detection in eyes of patients with relapsing-remitting multiple sclerosis () and from healthy control subjects () using latent class analysis. Model A: temporal pRNFL thickness as measured by Cirrus OCT; estimated prevalence of retinal thickness changes in the sample was 23.42%; 95% confidence interval (95CI) 18.50 to 29.17%. Model B: temporal pRNFL thickness as measured by Spectralis OCT; estimated prevalence of retinal thickness changes in the sample was 24.25%; 95% confidence interval (95CI) 19.26 to 30.04%.

SensitivitySpecificity
Estimate95CIEstimate95CI

Model A
 Cirrus average GCIPL96.34%76.11 to 99.54%97.05%92.77 to 98.83%
 Cirrus minimum GCIPL98.43%64.61 to 99.95%95.81%91.00 to 98.10%
 Cirrus temporal pRNFL58.41%45.82 to 70.00%93.91%89.56 to 96.52%
 Best corrected visual acuity6.14%2.32 to 15.30%98.59%95.72 to 99.54%
Model B
 Cirrus average GCIPL97.15%76.94 to 99.71%97.61%93.16 to 99.19%
 Cirrus minimum GCIPL96.41%81.48 to 99.39%95.43%90.80 to 97.78%
 Spectralis temporal pRNFL69.69%57.14 to 79.86%92.70%88.01 to 95.65%
 Best corrected visual acuity6.08%2.30 to 15.15%98.55%95.58 to 99.53%

GCIPL: ganglion cell-inner plexiform layers; pRNFL: peripapillary retinal nerve fiber layer.