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BioMed Research International
Volume 2014, Article ID 129048, 9 pages
http://dx.doi.org/10.1155/2014/129048
Research Article

Adipose Tissue-Derived Stem Cell Secreted IGF-1 Protects Myoblasts from the Negative Effect of Myostatin

1Applied Stem Cell Research Center, University Medical Center Regensburg, 93053 Regensburg, Germany
2Department of Trauma Surgery, Center of Plastic and Hand Surgery, University Medical Center Regensburg, 93053 Regensburg, Germany
3Department of Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, Germany
4Department of Obstetrics and Gynecology, University Medical Center Regensburg, 93053 Regensburg, Germany
5Department of Cranio-Maxillofacial Surgery, University Medical Center Regensburg, 93053 Regensburg, Germany
6Department of Dermatology, University Medical Center Regensburg, 93053 Regensburg, Germany

Received 5 October 2013; Accepted 3 December 2013; Published 23 January 2014

Academic Editor: Xiaowen Bai

Copyright © 2014 Sebastian Gehmert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Blake, A. Weir, S. E. Newey, and K. E. Davies, “Function and genetics of dystrophin and dystrophin-related proteins in muscle,” Physiological Reviews, vol. 82, no. 2, pp. 291–329, 2002. View at Google Scholar · View at Scopus
  2. J. R. Mendell, L. R. Rodino-Klapac, and V. Malik, “Molecular therapeutic strategies targeting Duchenne muscular dystrophy,” Journal of Child Neurology, vol. 25, no. 9, pp. 1145–1148, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. R. M. Lovering and P. G. De Deyne, “Contractile function, sarcolemma integrity, and the loss of dystrophin after skeletal muscle eccentric contraction-induced injury,” American Journal of Physiology—Cell Physiology, vol. 286, no. 2, pp. C230–C238, 2004. View at Google Scholar · View at Scopus
  4. L. J. Beaton, M. A. Tarnopolsky, and S. M. Phillips, “Contraction-induced muscle damage in humans following calcium channel blocker administration,” Journal of Physiology, vol. 544, no. 3, pp. 849–859, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. L. Croisier, G. Camus, I. Venneman et al., “Effects of training on exercise-induced muscle damage and interleukin 6 production,” Muscle & Nerve, vol. 22, no. 2, pp. 208–212, 1999. View at Google Scholar
  6. E. Kamanga-Sollo, M. S. Pampusch, M. E. White, and W. R. Dayton, “Role of insulin-like growth factor binding protein (IGFBP)-3 in TGF-beta- and GDF-8 (myostatin)-induced suppression of proliferation in porcine embryonic myogenic cell cultures,” Journal of Cellular Physiology, vol. 197, no. 2, pp. 225–231, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. J. N. Haslett, D. Sanoudou, A. T. Kho et al., “Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 23, pp. 15000–15005, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Passerini, P. Bernasconi, F. Baggi et al., “Fibrogenic cytokines and extent of fibrosis in muscle of dogs with X-linked golden retriever muscular dystrophy,” Neuromuscular Disorders, vol. 12, no. 9, pp. 828–835, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Bogdanovich, T. O. B. Krag, E. R. Barton et al., “Functional improvement of dystrophic muscle by myostatin blockade,” Nature, vol. 420, no. 6914, pp. 418–421, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Gregorevic, D. R. Plant, K. S. Leeding, L. A. Bach, and G. S. Lynch, “Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration,” American Journal of Pathology, vol. 161, no. 6, pp. 2263–2272, 2002. View at Google Scholar · View at Scopus
  11. S. Sadat, S. Gehmert, Y.-H. Song et al., “The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF,” Biochemical and Biophysical Research Communications, vol. 363, no. 3, pp. 674–679, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Di Rocco, M. G. Iachininoto, A. Tritarelli et al., “Myogenic potential of adipose-tissue-derived cells,” Journal of Cell Science, vol. 119, no. 14, pp. 2945–2952, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. N. M. Vieira, V. Brandalise, E. Zucconi et al., “Human multipotent adipose-derived stem cells restore dystrophin expression of Duchenne skeletal-muscle cells in vitro,” Biology of the Cell, vol. 100, no. 4, pp. 231–241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Heslop, J. E. Morgan, and T. A. Partridge, “Evidence for a myogenic stem cell that is exhausted in dystrophic muscle,” Journal of Cell Science, vol. 113, part 12, pp. 2299–2308, 2000. View at Google Scholar · View at Scopus
  15. A.-M. Rodriguez, D. Pisani, C. A. Dechesne et al., “Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse,” Journal of Experimental Medicine, vol. 201, no. 9, pp. 1397–1405, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Rehman, D. Traktuev, J. Li et al., “Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells,” Circulation, vol. 109, no. 10, pp. 1292–1298, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. C.-J. Xiong, P.-F. Li, Y.-L. Song et al., “Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression,” Journal of Cellular Biochemistry, vol. 114, no. 12, pp. 2708–2717, 2013. View at Publisher · View at Google Scholar
  18. W.-Y. Li, Y.-L. Song, C.-J. Xiong et al., “Insulin induces proliferation and cardiac differentiation of P19CL6 cells in a dose-dependent manner,” Development, Growth & Differentiation, vol. 55, no. 7, pp. 676–686, 2013. View at Publisher · View at Google Scholar
  19. J. R. Florini, D. Z. Ewton, and S. A. Coolican, “Growth hormone and the insulin-like growth factor system in myogenesis,” Endocrine Reviews, vol. 17, no. 5, pp. 481–517, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Yang, Y. Zhang, Y. Li, Z. Wu, and D. Zhu, “Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3β pathway and is antagonized by insulin-like growth factor,” Journal of Biological Chemistry, vol. 282, no. 6, pp. 3799–3808, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. C. McPherron, A. M. Lawler, and S.-J. Lee, “Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member,” Nature, vol. 387, no. 6628, pp. 83–90, 1997. View at Google Scholar · View at Scopus
  22. W. E. Taylor, S. Bhasin, J. Artaza et al., “Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells,” American Journal of Physiology—Endocrinology and Metabolism, vol. 280, no. 2, pp. E221–E228, 2001. View at Google Scholar · View at Scopus
  23. M. Thomas, B. Langley, C. Berry et al., “Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation,” Journal of Biological Chemistry, vol. 275, no. 51, pp. 40235–40243, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Ríos, I. Carneiro, V. M. Arce, and J. Devesa, “Myostatin regulates cell survival during C2C12 myogenesis,” Biochemical and Biophysical Research Communications, vol. 280, no. 2, pp. 561–566, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. M. E. Coleman, F. DeMayo, K. C. Yin et al., “Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice,” Journal of Biological Chemistry, vol. 270, no. 20, pp. 12109–12116, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. D. L. DeVol, P. Rotwein, J. L. Sadow, J. Novakofski, and P. J. Bechtel, “Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth,” American Journal of Physiology—Endocrinology and Metabolism, vol. 259, no. 1, pp. E89–E95, 1990. View at Google Scholar · View at Scopus
  27. P. Gregorevic, D. R. Plant, and G. S. Lynch, “Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice,” Muscle and Nerve, vol. 30, no. 3, pp. 295–304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. J. D. Molkentin and E. N. Olson, “Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9366–9373, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Yun and B. Wold, “Skeletal muscle determination and differentiation: story of a core regulatory network and its context,” Current Opinion in Cell Biology, vol. 8, no. 6, pp. 877–889, 1996. View at Publisher · View at Google Scholar · View at Scopus
  30. L. A. Megeney, B. Kablar, K. Garrett, J. E. Anderson, and M. A. Rudnicki, “MyoD is required for myogenic stem cell function in adult skeletal muscle,” Genes and Development, vol. 10, no. 10, pp. 1173–1183, 1996. View at Google Scholar · View at Scopus
  31. B. Langley, M. Thomas, A. Bishop, M. Sharma, S. Gilmour, and R. Kambadur, “Myostatin inhibits myoblast differentiation by down-regulating MyoD expression,” Journal of Biological Chemistry, vol. 277, no. 51, pp. 49831–49840, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Song, H. Wang, T. L. Krebs, and D. Danielpour, “Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation,” EMBO Journal, vol. 25, no. 1, pp. 58–69, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. A. U. Trendelenburg, A. Meyer, D. Rohner, J. Boyle, S. Hatakeyama, and D. J. Glass, “Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size,” American Journal of Physiology—Cell Physiology, vol. 296, no. 6, pp. C1258–C1270, 2009. View at Publisher · View at Google Scholar · View at Scopus