Mesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model

Figure 2

In vivo levels of BDNF assayed using immunostaining and ELISA. Seven days after MCAO, sections were obtained through the SVZ of the ischemic hemisphere ((a), MSCs and MSCs-BDNF: red; BDNF: green; scale bar: 100 μm, magnified image: 10 μm). The level of BDNF increased significantly in the ischemic hemisphere of animals in the MSCs and MSCs-BDNF groups compared with PBS-treated rats (b) (𝑡 test, *𝑃<0.05 and **𝑃<0.01).

(a)

(b)