Mesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model
In vivo levels of BDNF assayed using immunostaining and ELISA. Seven days after MCAO, sections were obtained through the SVZ of the ischemic hemisphere ((a), MSCs and MSCs-BDNF: red; BDNF: green; scale bar: 100 μm, magnified image: 10 μm). The level of BDNF increased significantly in the ischemic hemisphere of animals in the MSCs and MSCs-BDNF groups compared with PBS-treated rats (b) ( test, * and **).
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