Mesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model

Figure 3

Transplantation of MSCs-BDNF improved functional outcome after ischemia. (a) The MSCs and MSCs-BDNF groups exhibited better sensorimotor function compared with the PBS group (𝑛=5, each group). The MSCs-BDNF group exhibited the fastest recovery compared with the other groups (^∗𝑃<0.05). (b) The MSCs-BDNF group had better running function compared with the other groups at 28 days after MCAO (*𝑃<0.05). (c) Brain slices were stained with TTC to visualize lesions (𝑛=3, each group). (d) 14 days after MCAO, significant differences of %CIV were detected in each group (*𝑃<0.05 and **𝑃<0.01).

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