Mesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model
Transplantation of MSCs-BDNF improved functional outcome after ischemia. (a) The MSCs and MSCs-BDNF groups exhibited better sensorimotor function compared with the PBS group (, each group). The MSCs-BDNF group exhibited the fastest recovery compared with the other groups (). (b) The MSCs-BDNF group had better running function compared with the other groups at 28 days after MCAO (*). (c) Brain slices were stained with TTC to visualize lesions (, each group). (d) 14 days after MCAO, significant differences of %CIV were detected in each group (* and **).