BioMed Research International / 2014 / Article / Fig 3

Review Article

Ligation Strategies for Targeting Liposomal Nanocarriers

Figure 3

Bioorthogonal chemistry approaches for coupling ligands. Schematic representation of a cross section of a liposome bilayer containing functional groups to illustrate: (a) and (b) copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (CuAAC) ligation, (c) copper-free click chemistry ligation, (d) the Staudinger ligation, and (e) tetrazine/trans-cyclooctene inverse electron demand Diels-Alder cycloaddition (IEDDA). Coupling ligands are represented by a red star.