A Role for T-Lymphocytes in Human Breast Cancer and in Canine Mammary Tumors

Table 2

Studies of T-lymphocytic infiltrate in Canine mammary tumors (CMT).

Author	Year	Patients (𝑛)	Type	Comments
Estrela-Lima et al. [78]	2010	51	T-lymphocyte infiltration	Animals with high proportions of CD4+ and low CD8+ T-cells had lower survival rates
Kim et al. [79]	2010	58	T-lymphocyte infiltration	Association between the expression of TILs, cytokines, and mutation of BRCA1 suggests that all of these factors may play a role in tumor progression
Carvalho et al. [80]	2011	57	T-lymphocyte infiltration	Tendency for an association of a higher number of CD3+ TILs and a shorter overall survival. CD3+ T-lymphocytes in the adnexal nontumoral mammary gland revealed a statistically significant relationship with overall survival
Saeki et al. [81]	2012	140	Lymphocytic infiltration	Relationship of TILs and canine mammary tumors malignancy
Kim et al. [82]	2012	37	Regulatory T-cells (Treg)	The number of Treg cells is increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis
Kim et al. [83]	2013	47	Lymphocytic infiltration	Intense lymphocyte infiltration was associated with aggressive histologic features (higher histologic grade; lymphatic invasion)