Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 134260, 13 pages
http://dx.doi.org/10.1155/2014/134260
Research Article

Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats

1Emergency Hospital Floreasca, Bucharest 5, 8 Calea Floreasca, Sector 1, 014461 Bucharest, Romania
2National Institute of Materials Physics, 105 Bis Atomistilor, 077125 Magurele, Romania
3Faculty of Physics, University of Bucharest, 405 Atomistilor, 077125 Magurele, Romania
4ISTO, UMR 7327 CNRS, Université d’Orléans, 1A rue de la Férollerie, 45071 Orléans Cedex 2, France

Received 27 February 2014; Accepted 22 April 2014; Published 14 May 2014

Academic Editor: Amitava Mukherjee

Copyright © 2014 Alina Mihaela Prodan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Baratli, A. L. Charles, V. Wolff et al., “Impact of iron oxide nanoparticles on brain, heart, lung, liver and kidneys mitochondrial respiratory chain complexes activities and coupling,” Toxicology in Vitro, vol. 27, no. 8, pp. 2142–2148, 2013. View at Publisher · View at Google Scholar
  2. A. J. Ferreira, J. Cemlyn-Jones, and C. Robalo Cordeiro, “Nanoparticles, nanotechnology and pulmonary nanotoxicology,” Revista Portuguesa de Pneumologia, vol. 19, no. 1, pp. 28–37, 2012. View at Google Scholar
  3. M. Mahmoudi, S. Sant, B. Wang, S. Laurent, and T. Sen, “Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy,” Advanced Drug Delivery Reviews, vol. 63, no. 1-2, pp. 24–46, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Tari, R. W. Chantrell, S. W. Charles, and J. Popplewell, “The magnetic properties and stability of a ferrofluid containing Fe3O4 particles,” Physica B&C, vol. 97, no. 1, pp. 57–64, 1979. View at Google Scholar · View at Scopus
  5. P. Poizot, S. Laruelle, S. Grugeon, L. Dupont, and J.-M. Tarascon, “Nano-sized transition-metal oxides as negative-electrode materials for lithium-ion batteries,” Nature, vol. 407, no. 6803, pp. 496–499, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Mahmoudi, A. Simchi, M. Imani, P. Stroeve, and A. Sohrabi, “Templated growth of superparamagnetic iron oxide nanoparticles by temperature programming in the presence of poly(vinyl alcohol),” Thin Solid Films, vol. 518, no. 15, pp. 4281–4289, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Maleki, A. Simchi, M. Imani, and B. F. O. Costa, “Size-controlled synthesis of superparamagnetic iron oxide nanoparticles and their surface coating by gold for biomedical applications,” Journal of Magnetism and Magnetic Materials, vol. 324, no. 23, pp. 3997–4005, 2012. View at Publisher · View at Google Scholar
  8. M. F. Casula, P. Floris, C. Innocenti et al., “Magnetic resonance imaging contrast agents based on iron oxide superparamagnetic ferrofluids,” Chemistry of Materials, vol. 22, no. 5, pp. 1739–1748, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Brähler, R. Georgieva, N. Buske et al., “Magnetite-loaded carrier erythrocytes as contrast agents for magnetic resonance imaging,” Nano Letters, vol. 6, no. 11, pp. 2505–2509, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. H. H. K. Xu, D. T. Smith, and C. G. Simon, “Strong and bioactive composites containing nano-silica-fused whiskers for bone repair,” Biomaterials, vol. 25, no. 19, pp. 4615–4626, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Sokolov, M. Follen, J. Aaron et al., “Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles,” Cancer Research, vol. 63, no. 9, pp. 1999–2004, 2003. View at Google Scholar · View at Scopus
  12. Z. M. Qian, H. Li, H. Sun, and K. Ho, “Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway,” Pharmacological Reviews, vol. 54, no. 4, pp. 561–587, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Mahmoudi, A. Simchi, and M. Imani, “Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications,” Journal of the Iranian Chemical Society, vol. 7, no. 1, pp. S1–S27, 2010. View at Google Scholar · View at Scopus
  14. M. Mahmoudi, H. Hosseinkhani, M. Hosseinkhani et al., “Magnetic resonance imaging tracking of stem cells in vivo using iron oxide nanoparticles as a tool for the advancement of clinical regenerative medicine,” Chemical Reviews, vol. 111, no. 2, pp. 253–280, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Figuerola, R. di Corato, L. Manna, and T. Pellegrino, “From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications,” Pharmacological Research, vol. 62, no. 2, pp. 126–143, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Xu, C. Li, X. Kang et al., “Synthesis of a multifunctional nanocomposite with magnetic, mesoporous, and near-IR absorption properties,” The Journal of Physical Chemistry C, vol. 114, no. 39, pp. 16343–16350, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. T.-J. Yoon, K. N. Yu, E. Kim et al., “Specific targeting, cell sorting, and bioimaging with smart magnetic silica core-shell nanomaterials,” Small, vol. 2, no. 2, pp. 209–215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Siegel, D. Naishadham, and A. Jemal, “Cancer statistics, 2013,” CA: A Cancer Journal for Clinicians, vol. 63, pp. 11–30, 2013. View at Publisher · View at Google Scholar
  19. V. I. Shubayev, T. R. Pisanic II, and S. Jin, “Magnetic nanoparticles for theragnostics,” Advanced Drug Delivery Reviews, vol. 61, no. 6, pp. 467–477, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Wang, S. Zheng, Y. Shao, J. Liu, Z. Xu, and D. Zhu, “Amino-functionalized Fe3O4@SiO2 core-shell magnetic nanomaterial as a novel adsorbent for aqueous heavy metals removal,” Journal of Colloid and Interface Science, vol. 349, no. 1, pp. 293–299, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. D. N. Kapoor, A. Bansal, R. Sharma, and S. Dhawan, “advanced nanomedicine: present contributions and future expectations,” The American Journal of Phytomedicine and Clinical Therapeutics, vol. 1, no. 2, pp. 124–139, 2013. View at Google Scholar
  22. A. S. Arbab, B. Janic, J. Haller, E. Pawelczyk, W. Liu, and J. A. Frank, “In vivo cellular imaging for translational medical research,” Current Medical Imaging Reviews, vol. 5, no. 1, pp. 19–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Mahmoudi, I. Lynch, M. R. Ejtehadi, M. P. Monopoli, F. B. Bombelli, and S. Laurent, “Protein-nanoparticle interactions: opportunities and challenges,” Chemical Reviews, vol. 111, no. 9, pp. 5610–5637, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Bartolozzi, R. Lencioni, F. Donati, and D. Cioni, “Abdominal MR: liver and pancreas,” European Radiology, vol. 9, no. 8, pp. 1496–1512, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Meng, J. Fan, G. Galiana et al., “LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI,” Materials Science and Engineering C, vol. 29, no. 4, pp. 1467–1479, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M.-T. Zhu, Y. Wang, W.-Y. Feng et al., “Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells,” Journal of Nanoscience and Nanotechnology, vol. 10, no. 12, pp. 8584–8590, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Karmakar, Q. Zhang, and Y. Zhang, “Neurotoxicity of nanoscale materials,” Journal of Food and Drug Analysis, vol. 22, no. 1, pp. 147–160, 2014. View at Google Scholar
  28. V. Kulvietis, V. Zalgeviciene, J. Didziapetriene, and R. Rotomskis, “Transport of nanoparticles through the placental barrier,” Tohoku Journal of Experimental Medicine, vol. 225, no. 4, pp. 225–234, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. S. K. Lai, K. Hida, J. S. Suk et al., “Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus,” Nanotoxicology, vol. 6, no. 6, pp. 614–622, 2012. View at Publisher · View at Google Scholar
  30. M. Könczöl, S. Ebeling, E. Goldenberg et al., “Cytotoxicity and genotoxicity of size-fractionated iron oxide (magnetite) in A549 human lung epithelial cells: role of ROS, JNK, and NF-κB,” Chemical Research in Toxicology, vol. 24, no. 9, pp. 1460–1475, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Peters, R. Rückerl, and J. Cyrys, “Lessons from air pollution epidemiology for studies of engineered nanomaterials,” Journal of Occupational and Environmental Medicine, vol. 53, no. 6, pp. S8–S13, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. E. A. Eisen, S. Costello, J. Chevrier, and S. Picciotto, “Epidemiologic challenges for studies of occupational exposure to engineered nanoparticles; a commentary,” Journal of Occupational and Environmental Medicine, vol. 53, no. 6, supplement, pp. S57–S61, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. S. A. Palomares Sánchez, S. Ponce-Castañeda, J. R. Martínez, and F. Ruiz, “Determination of phases of α-Fe2O3:SiO2 compound by the rietveld refinement,” Revista Mexicana de Fisica, vol. 48, no. 5, pp. 438–442, 2002. View at Google Scholar · View at Scopus
  34. C. Qu, P. Gardner, and I. Schrijver, “The role of the cytoskeleton in the formation of gap junctions by Connexin 30,” Experimental Cell Research, vol. 315, no. 10, pp. 1683–1692, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Bai, L. Zhang, Y. Liu et al., “Pulmonary responses to printer toner particles in mice after intratracheal instillation,” Toxicology Letters, vol. 199, no. 3, pp. 288–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. G. E. Hatch, R. Slade, and E. Boykin, “Correlation of effects of inhaled versus intratracheally injected metals on susceptiblity to respiratory infection in mice,” The American Review of Respiratory Disease, vol. 124, no. 2, pp. 167–173, 1981. View at Google Scholar · View at Scopus
  37. B. Su, S. L. Xiang, J. Su et al., “Diallyl disulfide increases histone acetylation and P21WAF1 expression in human gastric cancer cells in vivo and in vitro,” Biochemical Pharmacology, vol. 1, no. 7, pp. 1–10, 2012. View at Google Scholar
  38. L. Lutterotti, “Total pattern fitting for the combined size-strain-stress-texture determination in thin film diffraction,” Nuclear Instruments and Methods in Physics Research B, vol. 268, no. 3-4, pp. 334–340, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Musić, Z. Orehovec, S. Popović, and I. Czakó-Nagy, “Structural properties of precipitates formed by hydrolysis of Fe3+ ions in Fe2(SO4)3 solutions,” Journal of Materials Science, vol. 29, no. 8, pp. 1991–1998, 1994. View at Publisher · View at Google Scholar · View at Scopus
  40. F. Izumi, A. Yamamoto, N. R. Khasanova, S. Kumazawa, W.-Z. Hu, and T. Kamiyama, “Novel techniques of neutron powder diffraction and their applications to superconducting oxides,” Physica C, vol. 335, no. 1, pp. 239–244, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. B. H. Toby, “R factors in Rietveld analysis: how good is good enough?” Powder Diffraction, vol. 21, no. 1, pp. 67–70, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. J. L. Dormann, L. Bessias, and D. Fiorani, “A dynamic study of small interacting particles: superparamagnetic model and spin-glass laws,” Journal of Physics C: Solid State Physics, vol. 21, pp. 2015–2034, 1988. View at Google Scholar
  43. S. H. Im, T. Herricks, Y. T. Lee, and Y. Xia, “Synthesis and characterization of monodisperse silica colloids loaded with superparamagnetic iron oxide nanoparticles,” Chemical Physics Letters, vol. 401, no. 1–3, pp. 19–23, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Guo, W. Yang, C. Wang, J. He, and J. Chen, “Poly(N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres: preparation, characterization, and biomedical applications,” Chemistry of Materials, vol. 18, no. 23, pp. 5554–5562, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. R. A. Pareta, E. Taylor, and T. J. Webster, “Increased osteoblast density in the presence of novel calcium phosphate coated magnetic nanoparticles,” Nanotechnology, vol. 19, no. 26, Article ID 265101, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. S. J. Soenen, B. Manshian, S. H. Doak, S. C. De Smedt, and K. Braeckmans, “Fluorescent non-porous silica nanoparticles for long-term cell monitoring: cytotoxicity and particle functionality,” Acta Biomaterialia, vol. 9, pp. 9183–9193, 2013. View at Publisher · View at Google Scholar
  47. J. Weichsel, N. Herold, M. J. Lehmann, H.-G. Kräusslich, and U. S. Schwarz, “A quantitative measure for alterations in the actin cytoskeleton investigated with automated high-throughput microscopy,” Cytometry Part A, vol. 77, no. 1, pp. 52–63, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. “Actin Cytoskeleton and Focal Adhesion Staining Kit,” Catalog No. FAK100, http://www.millipore.com/.
  49. F. Lu, S.-H. Wu, Y. Hung, and C.-Y. Mou, “Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles,” Small, vol. 5, no. 12, pp. 1408–1413, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. M.-H. Kim, H.-K. Na, Y.-K. Kim et al., “Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery,” ACS Nano, vol. 5, no. 5, pp. 3568–3576, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Hu, X. T. Zheng, J. S. Chen, M. Zhou, C. M. Li, and X. W. Lou, “Silica-based complex nanorattles as multifunctional carrier for anticancer drug,” Journal of Materials Chemistry, vol. 21, no. 22, pp. 8052–8056, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. P. J. A. Borm, “Particle toxicology: from coal mining to nanotechnology,” Inhalation Toxicology, vol. 14, no. 3, pp. 311–324, 2002. View at Google Scholar · View at Scopus
  53. J. Kim, S. Kim, and S. Lee, “Differentiation of the toxicities of silver nanoparticles and silver ions to the Japanese medaka (Oryzias latipes) and the cladoceran Daphnia magna,” Nanotoxicology, vol. 5, no. 2, pp. 208–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. D. Drobne, “Nanotoxicology for safe and sustainable nanotechnology,” Arhiv za Higijenu Rada i Toksikologiju, vol. 58, no. 4, pp. 471–478, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Seaton, “Nanotechnology and the occupational physician,” Occupational Medicine, vol. 56, no. 5, pp. 312–316, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. M.-T. Zhu, W.-Y. Feng, B. Wang et al., “Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats,” Toxicology, vol. 247, no. 2-3, pp. 102–111, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. P. V. Rajsekhar, G. Selvam, A. Goparaju, P. Balakrishna Murthy, and P. Neelakanta, “Reddy repeated inhalation exposure of manufactured fine and ultrafine aluminum oxide particles in mice,” Bulletin of Environment, Pharmacology and Life Sciences, vol. 1, no. 8, pp. 50–59, 2012. View at Google Scholar
  58. K.-I. Inoue, H. Takano, R. Yanagisawa et al., “Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice,” Environmental Health Perspectives, vol. 114, no. 9, pp. 1325–1330, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. W. MacNee and K. Donaldson, “How can ultrafine particles be responsible for increased mortality?” Monaldi Archives for Chest Disease, vol. 55, no. 2, pp. 135–139, 2000. View at Google Scholar · View at Scopus
  60. W. Wu, Q. He, and C. Jiang, “Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies,” Nanoscale Research Letters, vol. 3, no. 11, pp. 397–415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. X. He, H. Zhang, Y. Ma et al., “Lung deposition and extrapulmonary translocation of nano-ceria after intratracheal instillation,” Nanotechnology, vol. 21, no. 28, Article ID 285103, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. S. K. Nalabotu, M. B. Kolli, W. E. Triest et al., “Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats,” International Journal of Nanomedicine, vol. 6, pp. 2327–2335, 2011. View at Google Scholar
  63. Y. Li, J. Li, J. Yin et al., “Systematic influence induced by 3 nm titanium dioxide following intratracheal instillation of mice,” Journal of Nanoscience and Nanotechnology, vol. 10, no. 12, pp. 8544–8549, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. C. Jin, Y. Jin, J. Wang, and C. Zhao, “Comparative study of the effect on oxidative damage in rats inhaled by nano-sized and micro-sized silicon dioxide,” Wei Sheng Yan Jiu, vol. 37, no. 1, pp. 16–36, 2008. View at Google Scholar · View at Scopus
  65. B. Yang, Q. Wang, R. Lei et al., “Systems toxicology used in nanotoxicology: mechanistic insights into the hepatotoxicity of nano-copper particles from toxicogenomics,” Journal of Nanoscience and Nanotechnology, vol. 10, no. 12, pp. 8527–8537, 2010. View at Publisher · View at Google Scholar · View at Scopus