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BioMed Research International
Volume 2014, Article ID 134940, 7 pages
http://dx.doi.org/10.1155/2014/134940
Research Article

Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis

1Department of Pediatrics, Division of Pediatric Nephrology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
2Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
3Department of Pediatric Surgery, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
4Department of Pathology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
5Department of Nuclear Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
6Department of Microbiology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey

Received 14 February 2014; Revised 28 May 2014; Accepted 6 June 2014; Published 3 July 2014

Academic Editor: Pasquale Ditonno

Copyright © 2014 Elif Bahat Özdoğan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. This study aimed to demonstrate if the addition of anti-inflammatory treatment to antibiotic therapy shows any superiority to the treatment with antibiotic only. Methods. Forty-nine Wistar rats were divided into 7 groups. Pyelonephritis was performed by E. coli injection to upper pole of kidneys except control group. Group 2 was not treated. Ceftriaxone, ketoprofen, “ceftriaxone + ketoprofen,” methylprednisolone, and “ceftriaxone + methylprednisolone” were given in the groups. The technetium-99m-dimercaptosuccinic acid scintigraphies were performed in 3rd day to detect pyelonephritis and 10th week to detect renal scarring. All kidneys were also histopathologically evaluated. Results. When 3rd day and 10th week scintigraphies were compared, initial 2.00 ± 0.30 point pyelonephritis score resulted in 0.71 ± 0.36 renal scar score in “ceftriaxone + ketoprofen” group ( ). Initial 2.00 ± 0.43 point pyelonephritis score resulted in 0.86 ± 0.26 renal scar score in “ceftriaxone + methylprednisolone” group ( ). Renal scar score was declined in “ceftriaxone + ketoprofen” group and “ceftriaxone + methylprednisolone” group compared with no-treatment group on 10th week of the study ( , ). On histopathological evaluation, it was seen that renal scar prevalence and expansion declined significantly in “ceftriaxone + ketoprofen and ceftriaxone + methylprednisolone” ( , ). Conclusion. It was evidenced that ceftriaxone treatment in combination with ketoprofen or methylprednisolone declined scar formation in scintigraphic and histopathologic examinations of the kidneys.