Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes

Figure 1

The bone loss in Sod1 ^−/− mice. The treatment with 1% vitamin C in drinking water started from 4 weeks of age and continued for 12 weeks. Axial (upper panels) and coronal (lower panels) sections of μCT images of the distal ends of the femora of Sod1 ^+/+ and Sod1 ^−/− females at 16 weeks of age.