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BioMed Research International
Volume 2014, Article ID 140461, 5 pages
Clinical Study

Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients

1Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia
2Sydney Adventist Hospital Clinical School, The University of Sydney, Sydney, NSW 2076, Australia
3Sydney Eye Hospital, The University of Sydney, Sydney, NSW 2000, Australia

Received 19 February 2014; Revised 22 May 2014; Accepted 22 May 2014; Published 11 June 2014

Academic Editor: Ciro Costagliola

Copyright © 2014 Deepa Viswanathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients. Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min). Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D ( ) and 49.34 D ( ), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 ( ) and topometric astigmatism reduced from mean 3.50 D to 3.25 D ( ). Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.