Effects of Stress and MDMA on Hippocampal Gene Expression

Table 2

KEGG category rno04710 (circadian rhythm).

Entrez; ID	Symbol	Gene Name		Stress versus no stress
				No MDMA		MDMA
			Average intensity	−Fold change	𝑃 value	−Fold change	𝑃 value
29657	Arntl	Aryl hydrocarbon receptor nuclear translocator-like	135.80	−1.07	0.32	−1.08	0.12
63840	Per2	Period homolog 2 (Drosophila)	108.53	−1.21	0.01	−1.12	0.14
79431	Bhlhb2	Basic helix-loop-helix domain containing B2	638.68	−1.03	0.73	−1.07	0.15
299691	Cry1	Cryptochrome 1 (photolyase-like)	116.72	1.12	0.15	1.12	0.03
64462	Csnk1d	Casein kinase 1, delta	271.06	−1.05	0.37	−1.03	0.38
58822	Csnk1e	Casein kinase 1, epsilon	382.89	−1.02	0.74	−1.09	0.02
287422	Per1	Period homolog 1 (Drosophila)	165.79	−1.34	0.00	1.00	0.91
170917	Cry2	Cryptochrome 2 (photolyase-like)	540.10	−1.09	0.10	−1.13	0.01
60447	Clock	Circadian locomoter output cycles kaput	244.29	−1.14	0.02	1.01	0.84
252917	Nr1d1	Nuclear receptor 1D1	347.48	−1.34	0.00	−1.45	0.00
316351	Npas2	Neuronal PAS domain protein 2	255.91	−1.25	0.01	−1.24	0.00
78962	Per3	Period homolog 3 (Drosophila)	115.64	−1.10	0.25	−1.05	0.35

The average intensity of all genes shown is above threshold. Fold changes above or below threshold and significant 𝑃 values are shown in bold. On this basis, the italicized genes are judged to be suppressed by stress.