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BioMed Research International
Volume 2014, Article ID 142425, 11 pages
Review Article

Inflammation-Based Scores: A New Method for Patient-Targeted Strategies and Improved Perioperative Outcome in Cancer Patients

1Department of Anaesthesia and Intensive Care, Foundation IRCCS Policlinico San Matteo, P.le Golgi 19, 27100 Pavia, Italy
2SIMPAR (Study in Multidisciplinary Pain Research) Group, Italy
3Department of Surgical, Medical, Diagnostic and Pediatric Science, University of Pavia, Via Aselli 45, 27100 Pavia, Italy
4Pain Therapy Service, Foundation IRCCS Policlinico San Matteo, P.le Golgi 19, 27100 Pavia, Italy
5Department of Anesthesia and Perioperative Medicine, Catholic University of Louvain, St. Luc Hospital, 10 Avenue Hippocrate, 1200 Brussels, Belgium
6Department of Anesthesia and Intensive Care, University of Parma, Via Gramsci 14, 43126 Parma, Italy

Received 10 December 2013; Revised 10 March 2014; Accepted 19 March 2014; Published 27 April 2014

Academic Editor: Melchiorre Cervello

Copyright © 2014 Dario Bugada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Systemic inflammatory response (SIR) has actually been shown as an important prognostic factor associated with lower postoperative survival in several types of cancer. Thus, the challenge for physicians is to find specific, low-cost, and highlyreliable inflammatory markers, clearly correlated with prognosis and able to preoperatively stratify patient’s risk. Inflammation is a promising target to improve perioperative outcome, and data show that anti-inflammation techniques have a great potential in the perioperative period of cancer surgery. Inflammation scores could be useful to stratify patients with a potential better response to anti-inflammation strategies. Furthermore, inflammation scores could prevent failure of clinical trials by a better definition of patients to be included in such trials; inflammation scoring could clarify the real role of different drugs and techniques on outcome after cancer surgery, defining if different therapies are required for different patients. The role of this review is to focus on the currently available scores, in order to clarify their rationale and to analyze the actual evidence and limits, providing physicians with an updated overview of the possible inflammation-based prognostic scores for cancer patients undergoing surgery.