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BioMed Research International
Volume 2014, Article ID 145342, 9 pages
Review Article

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

1Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
2University College of Pharmacy, University of Punjab, Lahore 54000, Pakistan
3Department of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan
4Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan

Received 6 February 2014; Revised 2 April 2014; Accepted 14 April 2014; Published 29 May 2014

Academic Editor: George Perry

Copyright © 2014 Ghulam Murtaza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE in different disorders. The findings elaborate that CAPE is a versatile therapeutically active polyphenol and an effective adjuvant of chemotherapy for enhancing therapeutic efficacy and diminishing chemotherapy-induced toxicities.