Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

Table 3

Genotype and allele distribution of the IRS1 (G972R) gene polymorphism for GDM and non-GDM.

IRS1; (rs1801278)	GDM; 𝑁 (%)	Non-GDM; 𝑁 (%)	Odds ratio^a; (95% CI)	𝑃 value	Odds ratio^b (95% CI)	𝑃 value
𝑁	200	300
CC	189 (94.5)	295 (98.3)	Reference
CT	10 (5.0)	5 (1.7)	3.1 (0.99, 9.2)	0.06*	2.9 (0.89, 9.9)	0.07
TT	1 (0.5)	0 (0.0)	—	—
CT + TT	11 (5.5)	5 (1.7)	3.4 (1.2, 10.1)	0.02*	3.3 (1.0, 10.9)	0.04
C	388 (97)	595 (99.2)	Reference
T	12 (3)	5 (0.08)	3.7 (1.3, 10.5)	0.01

aCrude odds ratio (95% CI); ^bodds ratio (95% CI) adjusted for age and BMI.
*Genotype and allele frequency distribution with GDM and Non-GDM subjects.