Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

<div class="floats-full-page floats-full-page-other"><h2>Table 1</h2><div class="floats-full-page-caption">HME process parameters and drug-polymer composition of prepared formulations.</div><div class="floats-full-page-content"><table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="10"><hr /></td></tr><tr class="thead"><td align="left" rowspan="2">&#13;
                  Formulation codes</td><td align="center" rowspan="2">&#13;
                  &#13;
                  Batch size (gm)</td><td align="center" colspan="6">Formulation composition</td><td align="center" rowspan="2">&#13;
                  &#13;
                  Extrusion temp. (°C) &#13;
						 (speed 50 rpm for all)</td><td align="center" rowspan="2">&#13;
                  &#13;
                  Residence time  (min)</td></tr><tr class="thead"><td align="center">Drug (gm)</td><td align="center">Sol (gm)</td><td align="center">PEG400 (gm)</td><td align="center">LF127 (gm)</td><td align="center">LF68 (gm)</td><td align="center">TPGS (gm)</td></tr><tr><td class="thead-hr" colspan="10"><hr /></td></tr><tr><td align="left">PZ1</td><td align="center">60</td><td align="center">30</td><td align="center">29</td><td align="center">1</td><td align="center">—</td><td align="center">—</td><td align="center">—</td><td align="center">115</td><td align="center">7–9</td></tr><tr><td align="left">PZ2</td><td align="center">60</td><td align="center">30</td><td align="center">29</td><td align="center">—</td><td align="center">1</td><td align="center">—</td><td align="center">—</td><td align="center">114</td><td align="center">9–11</td></tr><tr><td align="left">PZ3</td><td align="center">60</td><td align="center">30</td><td align="center">29</td><td align="center">—</td><td align="center">—</td><td align="center">1</td><td align="center">—</td><td align="center">118</td><td align="center">10–12</td></tr><tr><td align="left">PZ4</td><td align="center">60</td><td align="center">30</td><td align="center">29</td><td align="center">—</td><td align="center">—</td><td align="center">—</td><td align="center">1</td><td align="center">112</td><td align="center">8–10</td></tr><tr class="table-tr"><td colspan="10"><hr class="tbody-hr" /></td></tr></table></td></tr></table></div></div>

Table 1 | Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

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Table 1: Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

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Table 1

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