BioMed Research International / 2014 / Article / Tab 1

Research Article

Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

Table 1

HME process parameters and drug-polymer composition of prepared formulations.

Formulation codes Batch size (gm)Formulation composition Extrusion temp. (°C) (speed 50 rpm for all) Residence time (min)
Drug (gm)Sol (gm)PEG400 (gm)LF127 (gm)LF68 (gm)TPGS (gm)

PZ160302911157–9
PZ260302911149–11
PZ3603029111810–12
PZ460302911128–10