BioMed Research International / 2014 / Article / Tab 2

Research Article

Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

Table 2

Solubility parameter calculation for drug polymer compatibility.

Drug and polymers MPa1/2 (not ≥7)Drug-polymer compatibility

PCZ9.043.1115.9318.57 (a)
Sol + PEG400(19.43 + 9.60)/214.51 (b)(a − b) = 4.06Miscible
Sol + LF127(19.43 + 11.20)/215.31 (c)(a − c) = 3.26Miscible
Sol + LF68(19.43 + 12.37)/215.9 (d)(a − d) = 2.67Miscible
Sol + TPGS(19.43 + 8.71)/214.07 (e)(a − e) = 4.5Miscible