BioMed Research International / 2014 / Article / Tab 4

Research Article

Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

Table 4

Florey Huggins interaction parameter ( ) of SD.

Ratio1/ mix1/ pureLHS Hf / Hf  drug 1/ 1 − 1/  Polymer1 − 1/ *  Polymer drug + 1 − 1/ *  Polymer 2 Polymer / Hf (  drug + 1 − 1/ *  Polymer) / Hf * 2 Polymer Left

PZ10.0086956520.0056708630.0030258.31469.014−0.12046830.520.50.510.5−0.301030.1989700041−0.02396958−0.1204683110.00302−0.025
PZ20.008771930.0056708630.0031018.31469.014−0.12046830.520.50.510.5−0.301030.1989700041−0.02396958−0.1204683110.0031−0.026
PZ30.0084745760.0056708630.0028048.31469.014−0.12046830.520.50.510.5−0.301030.1989700041−0.02396958−0.1204683110.0028−0.023
PZ40.0089285710.0056708630.0032588.31469.014−0.12046830.520.50.510.5−0.301030.1989700041−0.02396958−0.1204683110.00326−0.027