BioMed Research International / 2014 / Article / Tab 4 / Research Article
Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation Table 4 Florey Huggins interaction parameter (
) of SD.
Ratio 1/
mix 1/
pure LHS
Hf
/
Hf
drug
1/
1 − 1/
Polymer1 − 1/
*
Polymer
drug + 1 − 1/
*
Polymer
2 Polymer
/
Hf (
drug + 1 − 1/
*
Polymer)
/
Hf *
2 Polymer
Left
PZ1 0.008695652 0.005670863 0.003025 8.314 69.014 −0.1204683 0.5 2 0.5 0.5 1 0.5 −0.30103 0.198970004 1 −0.02396958 −0.120468311 0.00302 −0.025 PZ2 0.00877193 0.005670863 0.003101 8.314 69.014 −0.1204683 0.5 2 0.5 0.5 1 0.5 −0.30103 0.198970004 1 −0.02396958 −0.120468311 0.0031 −0.026 PZ3 0.008474576 0.005670863 0.002804 8.314 69.014 −0.1204683 0.5 2 0.5 0.5 1 0.5 −0.30103 0.198970004 1 −0.02396958 −0.120468311 0.0028 −0.023 PZ4 0.008928571 0.005670863 0.003258 8.314 69.014 −0.1204683 0.5 2 0.5 0.5 1 0.5 −0.30103 0.198970004 1 −0.02396958 −0.120468311 0.00326 −0.027
