Association of Immunological Cell Profiles with Specific Clinical Phenotypes of Scleroderma Disease

Table 2

Cell subpopulation percentages (medians) stratified by subsets.

Cell; population	Overall		Type			Pulmonary; fibrosis		Pulmonary; hypertension		Cardiac; affliction		Time since the diagnosis of the disease (years)			Corticosteroids; treatment (years)
	Controls; 𝑛=49	Patients; 𝑛=49	LSc; 𝑛=6	lcSSc; 𝑛=11	dcSSc; 𝑛=32	No; 𝑛=26	Yes; 𝑛=23	No; 𝑛=31	Yes; 𝑛=18	No; 𝑛=42	Yes; 𝑛=7	0–3; 𝑛=13	4–10; 𝑛=15	>10; 𝑛=21	No; 𝑛=21	0 to 3; 𝑛=17	>3; 𝑛=11
General
CD4^+ T-cells	65.04	62.46	62.36	66.17	63.84	62.36	63.84	65.66	62.19	62.46	68.35	64.16	63.84	61.91	62.31	62.46	65.46
CD8^+ T-cells	29.86	27.16	28.45	25.77	25.14	27.66	25.65	26.15	27.5	27.66	25.14	28.81	24.44	29.13	25.26	29.23	25.14
B cells	15.62	11.14	16.19	12.13	10.56	14.02	9.97	16.87	5.98 ^‡	12.39	6.19	12.51	12.13	11.01	18.50	10.56	9.97
NK cells	11.09	11.73	10.09	9.74	11.77	9.89	12.4	10.51	12.7	11.65	12.34	9.43	11.65	12.34	14.81	9.89	10.39
Monocytes	3.35	7.41	4.65	7.41	7.91	7.41	7.25	7.66	3.78	7.25	12.81	6.87	7.53	4.43	6.87	7.53	4.43
Activation
Overall	7.32	8.07	9.37	8.68	6.46	6.46	8.63	6.87	8.67	8.20	6.91	8.38	5.14	9.52 *	8.67	8.68	6.46
CD4^+ T-cells	5.05	6.88	7.81	8.47	5.78	5.78	7.21	5.54	7.08	6.69	7.99	8.17	4.67	7.44	5.23	7.69	6.69
CD8^+ T-cells	4.34	5.66	7.00	5.29	4.49	5.29	8.25	5.08	8.28	6.09	4.17	6.61	3.87	7.09	7.56	6.90	4.17
B cells	9.79	11.61	13.11	5.41	11.98	11.87	11.48	11.33	15.69 ^†	11.87	10.00	12.19	9.03	13.48	8.54	13.48	14.71
NK cells	14.93	19.57	24.57	22.41	15.68	18.41	21.39	18.99	22.44	19.57	21.30	23.27	11.76	23.48	17.05	23.09	17.71
Monocytes	70.80	70.10	81.75	66.67	61.90	77.36	59.42	74.88	61.52	74.75	58.60	62.93	84.68	61.90	84.45	70.66	50.00
Apoptosis
Overall	29.00	19.16	31.23	18.51	15.41	19.67	19.16	14.67	25.32 ^†	19.16	19.61	16.77	15.41	25.22	20.21	19.61	12.88
CD4^+ T-cells	22.56	17.48	22.61	13.97	11.05	17.66	17.48	11.10	21.88 ^†	17.48	21.36	13.23	11.05	22.79	18.44	18.22	11.05
CD8^+ T-cells	21.42	16.75	28.57	21.05	10.63	16.67	21.05	10.49	24.8	16.75	22.00	21.07	10.35	27.08	16.71	21.69	9.84
B cells	30.97	19.42	38.59	15.52	18.92	19.12	20.92	15.26	28.13 ^†	20.92	18.92	18.85	19.12	22.35	20.89	24.68	18.92
NK cells	45.68	35.43	68.02	37.93	30.77	37.93	32.67	33.10	45.32	36.69	32.67	37.31	27.99	40.81	31.18	47.54	33.33
Monocytes	80.00	62.90	59.67	65.97	62.90	58.58	66.67	58.32	67.48	62.90	62.04	57.44	62.04	66.26	62.93	66.41	55.88

Bold letters indicate statistically significant results relative to controls. ^‡Statistically significant compared to controls and without pulmonary hypertension. ^†Statistically significant relative to patients without pulmonary hypertension. *Indicate those data statistically significant compared to four and ten years from the diagnosis of the disease.