Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis: A Case-Control Study in a Chinese Han Population

Table 6

Association of the rs2234693 with knee OA in the Chinese Han population with a stratification by the severity of OA.

Groups compared	TT versus TC + CC			TT + TC versus CC			T allele versus C allele			All genotyped*
	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	𝑃 value
Mild OA (255 patients versus 514 controls)	1.322	0.963–1.815	0.084	1.560	1.056–2.304	0.025	1.302	1.050–1.615	0.016	0.047
Severe OA (214 patients versus 514 controls)	0.951	0.686–1.318	0.763	1.045	0.667–1.638	0.846	0.986	0.782–1.245	0.908	0.910

OR: Odds Ratio; CI: confidence interval.
∗TT, TC, and CC genotypes were grouped together and a 2×3 contingency-table analysis was performed.