GHK and DNA: Resetting the Human Genome to Health

Table 2

Ubiquitin/proteasome system and GHK.

Up	Gene title	Percent change in gene expression
1	Ubiquitin specific peptidase 29, USP29	1056
2	Ubiquitin protein ligase E3 component n-recognin 2, UBR2	455
3	Gamma-aminobutyric acid (GABA) B receptor, 1 /// ubiquitin D, GABBR1 /// UBD	310
4	Ubiquitin specific peptidase 34, USP34	195
5	Parkinson protein 2, E3 ubiquitin protein ligase (parkin), PARK2	169
6	Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), UBE2I	150
7	Ubiquitin protein ligase E3 component n-recognin 4, UBR4	146
8	Ubiquitin protein ligase E3B, UBE3B	116
9	Ubiquitin specific peptidase 2, USP2	104
10	Ubiquitin-like modifier activating enzyme 6, UBA6	104
11	Ubiquitination factor E4B (UFD2 homolog, yeast), UBE4B	97
12	Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), UBE2M	92
13	Ubiquitin-like modifier activating enzyme 7, UBA7	88
14	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1, HECW1	81
15	Proteasome (prosome, macropain) 26S subunit, ATPase, 3, PSMC3	81
16	Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast), UBE2D1	79
17	Proteasome (prosome, macropain) subunit, beta type, 2, PSMB2	79
18	Ubiquitin protein ligase E3 component n-recognin 5, UBR5	77
19	Ubiquitin specific peptidase 21, USP21	76
20	OTU domain, ubiquitin aldehyde binding 2, OTUB2	76
21	Proteasome (prosome, macropain) inhibitor subunit 1 (PI31), PSMF1	75
22	Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast), UBE2H	73
23	Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast), UBE2N	72
24	Ubiquitin carboxyl-terminal hydrolase L5, UCHL5	71
25	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13, PSMD13	70
26	Ubiquitin associated protein 1, UBAP1	70
27	Ubiquitin-conjugating enzyme E2B (RAD6 homolog), UBE2B	69
28	TMEM189-UBE2V1 readthrough /// ubiquitin-conjugating enzyme E2 variant 1, TMEM189-UBE2V1 /// UBE2V1	67
29	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1, PSMD1	64
30	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3, PSMD3	64
31	Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (drosophila), ARIH1	61
32	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BAP1	60
33	Ubiquitin interaction motif containing 1, UIMC1	60
34	Ubiquitin associated protein 2-like, UBAP2L	57
35	Ubiquitin protein ligase E3 component n-recognin 7 (putative), UBR7	56
36	Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast), UBE2G1	54
37	Itchy E3 ubiquitin protein ligase homolog (mouse), ITCH	54
38	Ubiquitin-conjugating enzyme E2D 4 (putative), UBE2D4	51
39	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, PSMD10	50
40	WW domain containing E3 ubiquitin protein ligase 1, WWP1	50
41	Ubiquitin-like 3, UBL3	50
Down	Gene title	Percent change in gene expression
1	Ubiquitin associated and SH3 domain containing A, UBASH3A	−89