Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 156010, 14 pages
http://dx.doi.org/10.1155/2014/156010
Research Article

Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation

1Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector 62, Noida, Uttar Pradesh 201307, India
2Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
3Division of CBRN Defense, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi 110054, India

Received 28 February 2014; Revised 28 May 2014; Accepted 2 June 2014; Published 14 July 2014

Academic Editor: Weiguo Dai

Copyright © 2014 Deepak Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [54 citations]

The following is the list of published articles that have cited the current article.

  • Deepak Sharma, Gilphy Philip, Reema Gabrani, Javed Ali, and Shweta Dang, “Dual agents loaded polymeric nanoparticle: Effect of process variables.,” International journal of pharmaceutical investigation, vol. 5, no. 3, pp. 155–60, . View at Publisher · View at Google Scholar
  • Tobias Führmann, Mousumi Ghosh, Anthony Otero, Ben Goss, Tim R. Dargaville, Damien D. Pearse, and Paul D. Dalton, “Peptide-functionalized polymeric nanoparticles for active targeting of damaged tissue in animals with experimental autoimmune encephalomyelitis,” Neuroscience Letters, 2015. View at Publisher · View at Google Scholar
  • Jian Shi, “Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers,” Acta Pharmacologica Sinica, vol. 36, no. 2, pp. 149–157, 2015. View at Publisher · View at Google Scholar
  • Deepak Sharma, Rakesh Kumar Sharma, Navneet Sharma, Reema Gabrani, Sanjeev K. Sharma, Javed Ali, and Shweta Dang, “Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles,” AAPS PharmSciTech, 2015. View at Publisher · View at Google Scholar
  • Sanjeev R Acharya, and Padmanabha RV Reddy, “Brain targeted delivery of paclitaxel using endogenous ligand,” Asian Journal of Pharmaceutical Sciences, 2015. View at Publisher · View at Google Scholar
  • María E. Ruiz, and Guillermo R. Castro, “Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies,” Antiepileptic Drug Discovery, pp. 299–326, 2016. View at Publisher · View at Google Scholar
  • Nazlı Erdoğar, Güneş Esendağlı, Thorbjorn T. Nielsen, Murat Şen, Levent Öner, and Erem Bilensoy, “Design and optimization of novel paclitaxel-loaded folate-conjugated amphiphilic cyclodextrin nanoparticles,” International Journal of Pharmaceutics, 2016. View at Publisher · View at Google Scholar
  • Zachary N. Warnken, Hugh D.C. Smyth, Alan B. Watts, Steve Weitman, John G. Kuhn, and Robert O. Williams, “Formulation and Device Design to Increase Nose to Brain Drug Delivery,” Journal of Drug Delivery Science and Technology, 2016. View at Publisher · View at Google Scholar
  • Aseem Bhatnagar, Sanjeev K. Sharma, Javed Ali, Shweta Dang, Deepak Sharma, Rakesh Kumar Sharma, Dhruv K. Nishad, Thakuri Singh, and Reema Gabrani, “Nose to brain delivery of midazolam loaded PLGA nanoparticles: In vitro and in vivo investigations,” Current Drug Delivery, vol. 13, no. 4, pp. 557–564, 2016. View at Publisher · View at Google Scholar
  • Mirza Salman Baig, Abdul Ahad, Mohammed Aslam, Syed Sarim Imam, Mohd Aqil, and Asgar Ali, “Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in ,” International Journal Of Biological Macromolecules, vol. 85, pp. 258–270, 2016. View at Publisher · View at Google Scholar
  • Ravi R. Patel, Sundeep Chaurasia, Gayasuddin Khan, Pramila Chaubey, Nagendra Kumar, and Brahmeshwar Mishra, “Cromolyn sodium encapsulated PLGA nanoparticles: An attempt to improve intestinal permeation,” International Journal of Biological Macromolecules, vol. 83, pp. 249–258, 2016. View at Publisher · View at Google Scholar
  • Oihane Gartziandia, Susana Patricia Egusquiaguirre, John Bianco, José Luis Pedraz, Manoli Igartua, Rosa Maria Hernandez, Véronique Préat, and Ana Beloqui, “Nanoparticle transport across in vitro olfactory cell monolayers,” International Journal of Pharmaceutics, vol. 499, no. 1-2, pp. 81–89, 2016. View at Publisher · View at Google Scholar
  • Getahun Paulos, Yahya Mrestani, Frank Heyroth, Tsige Gebre-Mariam, and Reinhard H.H. Neubert, “Fabrication of acetylated dioscorea starch nanoparticles: Optimization of formulation and process variables,” Journal of Drug Delivery Science and Technology, vol. 31, pp. 83–92, 2016. View at Publisher · View at Google Scholar
  • Ruiz-Ortega, Lafuente, Pedraz, Ugedo, Hernández, Gartziandia, Herrán, Miguelez, and Igartua, “Intranasal administration of chitosan-coated nanostructured lipid carriers loaded with GDNF improves behavioral and histological recovery in a partial lesion model of Parkinson's disease,” Journal of Biomedical Nanotechnology, vol. 12, no. 12, pp. 2220–2230, 2016. View at Publisher · View at Google Scholar
  • Nevine S. Abdelmalak, Marianne J. Naguib, Ahmed B. Ibrahim, Samia A. Nour, and Hassan M. Rashed, “Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies,” Drug Delivery, vol. 23, no. 9, pp. 3681–3695, 2016. View at Publisher · View at Google Scholar
  • Syed Zajif Hussain, Sohail Akhtar, Salma Batool, Rahman Shah Zaib Saleem, Muhammad Farhan Sohail, Irshad Hussain, Gul Shahnaz, Ibrahim Javed, Shoaib Sarwar, Akhtar Nadhman, and Nadeem Irfan Bukhari, “Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel,” Journal of Materials Chemistry B, vol. 4, no. 37, pp. 6240–6248, 2016. View at Publisher · View at Google Scholar
  • Ana Loureiro, Nuno G. Azoia, Andreia C. Gomes, and Artur Cavaco-Paulo, “Albumin-Based Nanodevices as Drug Carriers,” Current Pharmaceutical Design, vol. 22, no. 10, pp. 1371–1390, 2016. View at Publisher · View at Google Scholar
  • Surajit Bhattacharjee, Biplab Sarkar, Ashish Ranjan Sharma, Priya Gupta, Garima Sharma, Sang-Soo Lee, and Chiranjib Chakraborty, “Formulation and Application of Biodegradable Nanoparticles Based Biopharmaceutical Delivery - An Efficient Delivery System,” Current Pharmaceutical Design, vol. 22, no. 20, pp. 3020–3033, 2016. View at Publisher · View at Google Scholar
  • Furqan A. Maulvi, Harsh H. Choksi, Ankita R. Desai, Akanksha S. Patel, Ketan M. Ranch, Bhavin A. Vyas, and Dinesh O. Shah, “pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage,” Colloids and Surfaces B: Biointerfaces, vol. 157, pp. 72–82, 2017. View at Publisher · View at Google Scholar
  • S. Salatin, J. Barar, M. Barzegar-Jalali, Kh. Adibkia, and M. Jelvehgari, “Thermosensitive in situ nanocomposite as an intranasal delivery system of rivastigmine hydrogen tartrate: development, characterization, ex vivo permeation and cellular studies,” Colloids and Surfaces B: Biointerfaces, 2017. View at Publisher · View at Google Scholar
  • Md. Habban Akhter, and Saima Amin, “An investigative approach to treatment modalities for squamous cell carcinoma of skin,” Current Drug Delivery, vol. 14, no. 5, pp. 597–612, 2017. View at Publisher · View at Google Scholar
  • Maria Mir, Naveed Ahmed, and Asim ur Rehman, “Recent Applications Of Plga Based Nanostructures In Drug Delivery,” Colloids and Surfaces B: Biointerfaces, 2017. View at Publisher · View at Google Scholar
  • Annette Lasham, Andrew N. Shelling, Raida Al-Kassas, and Brenda Brenner S. Cerqueira, “Development of biodegradable PLGA nanoparticles surface engineered with hyaluronic acid for targeted delivery of paclitaxel to triple negative breast cancer cells,” Materials Science and Engineering C, vol. 76, pp. 593–600, 2017. View at Publisher · View at Google Scholar
  • Niyaz Ahmad, “Rasagiline-Encapsulated Chitosan Coated PLGA Nanoparticles Targeted to the Brain in the Treatment of Parkinson's Disease,” Journal of Liquid Chromatography & Related Technologies, 2017. View at Publisher · View at Google Scholar
  • Nandhakumar Sathyamoorthy, Dhanaraju Magharla, Pavankumar Chintamaneni, and Sundar Vankayalu, “Optimization of paclitaxel loaded poly (ε-caprolactone) nanoparticles using box behnken design,” Beni-Suef University Journal of Basic and Applied Sciences, 2017. View at Publisher · View at Google Scholar
  • Harsh Vardhan, Pooja Mittal, Sandeep K. Reddy Adena, Mansi Upadhyay, and Brahmeshwar Mishra, “Development of long-circulating docetaxel loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles: optimization, pharmacokinetic, cytotoxicity and in vivo assessments,” International Journal of Biological Macromolecules, 2017. View at Publisher · View at Google Scholar
  • Nandhakumar Sathyamoorthy, Dhanaraju Dasaratha Magharla, and Sundar Devendaran Vankayalu, “Effect of surface modification on the in vitro protein adsorption and cell cytotoxicity of vinorelbine nanoparticles,” Journal of Pharmacy and Bioallied Sciences, vol. 9, no. 2, pp. 135–143, 2017. View at Publisher · View at Google Scholar
  • Mohammad Barzegar-Jalali, Khosro Adibkia, Sara Salatin, Jaleh Barar, Farhad Kiafar, and Mitra Jelvehgari, “Development of a nanoprecipitation method for the entrapment of a very water soluble drug into Eudragit RL nanoparticles,” Research in Pharmaceutical Sciences, vol. 12, no. 1, pp. 1–14, 2017. View at Publisher · View at Google Scholar
  • Velichka Andonova, “Synthetic Polymer-Based Nanoparticles: Intelligent Drug Delivery Systems,” Acrylic Polymers in Healthcare, 2017. View at Publisher · View at Google Scholar
  • Dalia H. Abdelkader, Sanaa A. El-Gizawy, Ahmed M. Faheem, Paul A. McCarron, and Mohamed A. Osman, “Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: An optimisation study,” Journal of Drug Delivery Science and Technology, 2017. View at Publisher · View at Google Scholar
  • Srinivasan Saisivam, Abdelwahab Omri, and Sujit Kumar Debnath, “PLGA Ethionamide Nanoparticles for Pulmonary Delivery: Development and in vivo evaluation of dry powder inhaler,” Journal of Pharmaceutical and Biomedical Analysis, vol. 145, pp. 854–859, 2017. View at Publisher · View at Google Scholar
  • Sara M. Navarro, Sean Swetledge, Timothy Morgan, Carlos E. Astete, Rhett Stout, Diana Coulon, and Cristina M. Sabliov, “Biodistribution of orally administered poly(lactic-co-glycolic) acid nanoparticles for 7 days followed by 21 day recovery in F344 rats,” NanoImpact, vol. 5, pp. 1–5, 2017. View at Publisher · View at Google Scholar
  • Vilwanathan Ravikumar, and Renu Sankar, “Preparation of histone deacetylase inhibitor vorinostat-loaded poly D, L-lactide-co-glycolide polymeric nanoparticles by nanoprecipitation method,” Methods in Molecular Biology, vol. 1510, pp. 399–403, 2017. View at Publisher · View at Google Scholar
  • Shweta Gupta, Rajesh Kesarla, Narendra Chotai, Ambikanandan Misra, and Abdelwahab Omri, “Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability,” BioMed Research International, vol. 2017, pp. 1–18, 2017. View at Publisher · View at Google Scholar
  • Ghulam Abbas, Muhammad Hanif, and Mahtab Ahmad Khan, “pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design,” Designed Monomers and Polymers, vol. 20, no. 1, 2017. View at Publisher · View at Google Scholar
  • Divya Jyothi, Sneh Priya, and Jainey P James, “Development of nanoparticulate hydrogel loaded with crossandra infundibuliformis extract,” Journal of Young Pharmacists, vol. 9, no. 1, pp. 78–82, 2017. View at Publisher · View at Google Scholar
  • Vagner de Oliveira Machado, Ângela Leão Andrade, Alice Simon, Daniel Ernesto Rodríguez-Fernández, José Domingos Fabris, Rosana Zacarias Domingues, Raphael Ferreira da Silva, Thamiris Caroline Esteves Silva, Thainá Lopes Peixoto, Cláudio Teodoro dos Santos, Adriana Cristina Motta, Eliana Aparecida de Rezende Duek, Messias Borges Silva, Alaelson Vieira Gomes, Lúcio Mendes Cabral, Flávia Almada do Carmo, and Carlos Nelson Elias, “Development of a novel nano-biomaterial for biomedical applications,” Materials Research Express, vol. 5, no. 12, pp. 125014, 2018. View at Publisher · View at Google Scholar
  • Seyedeh Sara Esnaashari, and Amir Amani, “Optimization of Noscapine-Loaded mPEG-PLGA Nanoparticles and Release Study: a Response Surface Methodology Approach,” Journal of Pharmaceutical Innovation, vol. 13, no. 3, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Ilva D. Rupenthal, and Rohit Bisht, “PLGA nanoparticles for intravitreal peptide delivery: statistical optimization, characterization and toxicity evaluation,” Pharmaceutical Development and Technology, vol. 23, no. 4, pp. 324–333, 2018. View at Publisher · View at Google Scholar
  • Ghulam Abbas, and Muhammad Hanif, “Development and pharmacokinetic evaluation of alginate-pectin polymeric rafts forming tablets using box behnken design,” Drug Development and Industrial Pharmacy, vol. 44, no. 12, pp. 2026–2037, 2018. View at Publisher · View at Google Scholar
  • Kusum Devi Vemula, and Mahima Mathur, “Investigation of different types of nano drug delivery systems of atorvastatin for the treatment of hyperlipidemia,” Drug Development and Industrial Pharmacy, vol. 44, no. 12, pp. 2048–2060, 2018. View at Publisher · View at Google Scholar
  • Sara Salatin, Jaleh Barar, Mohammad Barzegar-Jalali, Khosro Adibkia, Farhad Kiafar, and Mitra Jelvehgari, “An Alternative Approach for Improved Entrapment Efficiency of Hydrophilic Drug Substance in PLGA Nanoparticles by Interfacial Polymer Deposition Following Solvent Displacement,” Jundishapur Journal of Natural Pharmaceutical Products, vol. 13, no. 4, 2018. View at Publisher · View at Google Scholar
  • Teresa Musumeci, Maria Francesca Serapide, Rosalia Pellitteri, Alessandro Dalpiaz, Luca Ferraro, Roberta Dal Magro, Angela Bonaccorso, Claudia Carbone, Francisco Veiga, Giulio Sancini, and Giovanni Puglisi, “Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents,” European Journal of Pharmaceutics and Biopharmaceutics, 2018. View at Publisher · View at Google Scholar
  • Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, and Sveinbjörn Gizurarson, “Evaluation of intranasal delivery route of drug administration for brain targeting,” Brain Research Bulletin, 2018. View at Publisher · View at Google Scholar
  • Sujit Kumar Debnath, Srinivasan Saisivam, Monalisha Debanth, and Abdelwahab Omri, “Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide,” Plos One, vol. 13, no. 1, pp. e0190976, 2018. View at Publisher · View at Google Scholar
  • Rania Abdel Baset Sanad, Nevine Shawky Abdelmalk, Randa Latif Aziz, Faisal A. Torad, and Reham Waheed Hammad, “Intranasal Surface-Modified Mosapride Citrate-Loaded Nanostructured Lipid Carriers (MOS-SMNLCs) for Treatment of Reflux Diseases: In vitro Optimization, Pharmacodynamics, and Pharmacokinetic Studies,” AAPS PharmSciTech, 2018. View at Publisher · View at Google Scholar
  • Bhavin Y. Gajera, Dhaval A. Shah, and Rutesh H. Dave, “Investigating a Novel Hot Melt Extrusion-Based Drying Technique to Solidify an Amorphous Nanosuspension Using Design of Experiment Methodology,” AAPS PharmSciTech, 2018. View at Publisher · View at Google Scholar
  • Laurian Vlase, Lucia Ruxandra Tefas, Lucia Maria Rus, Marcela Achim, and Ioan Tomuță, “Application of the quality by design concept in the development of quercetin-loaded polymeric nanoparticles,” Farmacia, vol. 66, no. 5, pp. 798–810, 2018. View at Publisher · View at Google Scholar
  • Leonardo M.B. Ferreira, Charlene P. Kiill, Liliane N. Pedreiro, Aline M. Santos, and Maria Palmira D. Gremião, “Supramolecular design of hydrophobic and hydrophilic polymeric nanoparticles,” Design and Development of New Nanocarriers, pp. 181–221, 2018. View at Publisher · View at Google Scholar
  • Deepika Deepika, Hitesh Kumar Dewangan, Lakshmi Maurya, and Sanjay Singh, “Intranasal Drug Delivery of Frovatriptan Succinate–Loaded Polymeric Nanoparticles for Brain Targeting,” Journal of Pharmaceutical Sciences, 2018. View at Publisher · View at Google Scholar
  • Imran Ahmad, Jayamanti Pandit, Yasmin Sultana, Anil K. Mishra, Puja Panwar Hazari, and Mohd. Aqil, “Optimization by design of etoposide loaded solid lipid nanoparticles for ocular delivery: Characterization, pharmacokinetic and deposition study,” Materials Science and Engineering: C, 2019. View at Publisher · View at Google Scholar
  • Teresa Musumeci, Angela Bonaccorso, and Giovanni Puglisi, “Epilepsy Disease and Nose-to-Brain Delivery of Polymeric Nanoparticles: An Overview,” Pharmaceutics, vol. 11, no. 3, pp. 118, 2019. View at Publisher · View at Google Scholar
  • Nagarjun Rangaraj, Hanumanth Srikanth Cheruvu, Sunitha Sampathi, Pravin Patel, Sravanthi Reddy Pailla, and Sujatha Dodoala, “Quality by Design Approach for Developing Lipid-Based Nanoformulations of Gliclazide to Improve Oral Bioavailability and Anti-Diabetic Activity,” AAPS PharmSciTech, vol. 20, no. 2, 2019. View at Publisher · View at Google Scholar
  • Juhi Samal, Ana Lucia Rebelo, and Abhay Pandit, “A window into the brain: Tools to assess preclinical efficacy of biomaterials-based therapies on central nervous system disorders,” Advanced Drug Delivery Reviews, 2019. View at Publisher · View at Google Scholar