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BioMed Research International
Volume 2014, Article ID 156010, 14 pages
http://dx.doi.org/10.1155/2014/156010
Research Article

Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation

Deepak Sharma,1 Dipika Maheshwari,1 Gilphy Philip,1 Ravish Rana,1 Shanu Bhatia,1 Manisha Singh,1 Reema Gabrani,1 Sanjeev K. Sharma,1 Javed Ali,2 Rakesh Kumar Sharma,3 and Shweta Dang1

1Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector 62, Noida, Uttar Pradesh 201307, India
2Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
3Division of CBRN Defense, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi 110054, India

Received 28 February 2014; Revised 28 May 2014; Accepted 2 June 2014; Published 14 July 2014

Academic Editor: Weiguo Dai

Copyright © 2014 Deepak Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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