BioMed Research International / 2014 / Article / Tab 1

Research Article

Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation

Table 1

Independent and dependent variables levels in Box-Behnken design.


Independent variables
= polymer concentration (w/v)103560
= surfactant concentration (w/v)28.5015
= aqueous/organic phase ratio (v/v)2610
= drug concentration (w/v)135

Dependent Variables:Constraints
= -average (d·nm)Minimize
= % drug entrapmentMaximize