Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth
Figure 1
(a) Growth of Streptococcus pneumoniae with different concentrations of sinefungin (10 μg to 50 μg mL−1) in time course experiment. 1 : 100 diluted cell suspensions were grown with different concentrations of sinefungin at different time points (0, 2, 4, 6, 8, and 10 h) at 37°C in 5% CO2 and optical density was measured at 600 nm. (b) CFU counts of pneumococci grown with different concentrations of sinefungin at 6 hours. After 6 h of incubation, 100 μL aliquots were serially diluted and plated on blood agar plate to enumeration bacteria. Error bars represent the standard deviation of the mean values.
