Evolution of Network Biomarkers from Early to Late Stage Bladder Cancer Samples

Table 2

The 18 identified significant proteins of core network marker in both early and late stage bladder cancers.

Common network marker of early and late stage bladder cancer
Protein	CRV-early	P value-early	CRV-late	P value-late
UBC	29.91709	<1e − 5	158.5321	<1e − 5
CUL3	27.96694	<1e − 5	13.0117	<1e − 5
CUL5	14.97713	<1e − 5	4.834916	0.002872
RPL22	10.47367	<1e − 5	8.110447	<1e − 5
SUMO2	8.391421	<1e − 5	10.34113	<1e − 5
APP	6.933807	<1e − 5	11.47363	<1e − 5
SH3KBP1	6.765387	<1e − 5	4.447911	0.00619
PTBP1	6.740458	<1e − 5	4.511016	0.005506
ELAVL1	6.635085	<1e − 5	10.77056	<1e − 5
SIRT7	5.55441	3.13E − 05	7.656515	<1e − 5
MYC	4.6109	0.00072	13.0423	<1e − 5
HSP90AA1	4.60136	0.00072	6.513345	0.000123
COPS5	3.898548	0.003163	6.601779	9.22E − 05
ESR1	3.873735	0.003383	5.6189	0.000614
BRCA1	3.788256	0.00415	11.5863	<1e − 5
TERF2IP	3.680287	0.00487	5.202998	0.00149
SOX2	3.534024	0.007219	5.495338	0.00076
CUL1	3.521039	0.00736	13.2669	<1e − 5