Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
Enrichment of NRF2 target genes in samples harboring complex component gene alteration. (a) Enrichment of the different NRF2 target gene sets (Section 2). Enrichment scores (ES) are depicted for each sample. Increasing shades of red denote a larger ES. White boxes denote negative enrichment of NRF2 target genes (ES < 0). (b) Histogram for ES values across 502 samples with alterations affecting complex components genes.