Figure 3: Diabetic rat model was established by 8-week HFHSD administration followed by thrice intraperitoneal injection of low doses of 30 mg/kg STZ. Nontreated rats served as control group. Diet-STZ-induced diabetic rats were treated with or without 120 mg/kg metformin (DH) and Cordyceps militaris extracts at various doses for another 3 weeks. The changes fasting plasma glucose level (a) and pyruvate kinase activity (b) were determined. Data are expressed as mean ± SD ( ) and analyzed using one-way ANOVA followed by Dunn’s test. versus controls, , , and versus DM group. CT: control rats; DM: diabetic rats; AE: alcohol extract; WE: water extract.